Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
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Cites background from "Induction of Pluripotent Stem Cells..."
...Importantly, Takahashi et al. (2007) showed that the human iPS cells could be directed down the cardiomyocyte lineage using activin/ BMP4 and toward neurons using PA6 stromal cell coculture....
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...Additionally, the ability to derive patient-specific ESC equivalents (Park et al., 2008; Takahashi et al., 2007; Yu et al., 2007) provides powerful new tools to evade the immune system, study basic disease mechanisms, and establish screens for drug discovery (see Review by R. Jaenisch and R. Young,…...
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...These studies demonstrated reprogramming of either the differentiated progeny of stem cells (Park et al., 2008), fetal and neonatal fibroblasts (Yu et al., 2007), or adult fibroblasts (Takahashi et al., 2007)....
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References
23,959 citations
"Induction of Pluripotent Stem Cells..." refers background in this paper
...We showed that induced pluripotent stem (iPS) cells can be generated from mouse embryonic fibroblasts (MEF) and adult mouse tail-tip fibroblasts by the retrovirus-mediated transfection of four transcription factors, namely Oct3/4, Sox2, c-Myc, and Klf4 (Takahashi and Yamanaka, 2006)....
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...Induction of iPS cells from mouse fibroblasts requires retroviruses with high transduction efficiencies (Takahashi and Yamanaka, 2006)....
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...Optimization of Retroviral Transduction for Generating Human iPS Cells Induction of iPS cells from mouse fibroblasts requires retroviruses with high transduction efficiencies (Takahashi and Yamanaka, 2006)....
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15,555 citations
"Induction of Pluripotent Stem Cells..." refers background in this paper
...These properties have led to expectations that human ES cells might be useful to understand disease mechanisms, to screen effective and safe drugs, and to treat patients of various diseases and injuries, such as juvenile diabetes and spinal cord injury (Thomson et al., 1998)....
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8,144 citations
"Induction of Pluripotent Stem Cells..." refers background in this paper
...Embryonic stem (ES) cells, derived from the inner cell mass of mammalian blastocysts, have the ability to grow indefinitely while maintaining pluripotency (Evans and Kaufman, 1981; Martin, 1981)....
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"Induction of Pluripotent Stem Cells..." refers background in this paper
...The function of Oct3/4 and Sox2 as core transcription factors to determine pluripotency is well documented (Boyer et al., 2005; Loh et al., 2006; Wang et al., 2006)....
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