Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides.
Citations
479 citations
470 citations
397 citations
383 citations
References
3,556 citations
1,465 citations
"Industrial-scale manufacturing of p..." refers background in this paper
...Several studies in the past few decades have established that bioactive peptides have certain bio-functionalities and may therefore serve therapeutic roles in body systems (Hancock and Sahl, 2006; Huang et al., 2010; Kim andWijesekara, 2010; Korhonen and Pihlanto, 2006)....
[...]
...Second, the proteases of most microorganisms, especially the Lactic Acid Bacteria are expressed on the cell-membrane making harvesting and purification relatively cheap and less laborious....
[...]
...…is more efficient under industrial-scale conditions and less costive than the convectional batch methods and it is achieved by the use of compartmentalized ultrafiltration membrane reactors which may or may not be coupled with other purification techniques/units (Korhonen and Pihlanto, 2006)....
[...]
...Another common approach is the use of continuous processes which has been widely applied for total conversion of food proteins of various origins to hydrolysates with improved nutritional and/or functional properties (Korhonen and Pihlanto, 2006)....
[...]
...The unavailability of large scale technologies and high cost of purification techniques are a limiting factor to the commercialization of peptide-based products (Korhonen and Pihlanto, 2006)....
[...]
986 citations
652 citations
519 citations
"Industrial-scale manufacturing of p..." refers background in this paper
...Bioactive peptides are protein hydrolysates that can induce beneficial physiological responses in the human body (Möller et al., 2008)....
[...]
...The functional abilities of bioactive peptides have therefore aroused a lot of scientific, technological and consumer interest as regards the role of dietary proteins in controlling and influencing health (Möller et al., 2008)....
[...]