Inflammation and Alzheimer's disease.
Citations
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Cites background from "Inflammation and Alzheimer's diseas..."
...Moreover, microglia surrounding plaques stain positive for activation markers and proinflammatory mediators, including MHC class II, Cox-2, MCP-1, TNF-a, IL-1b, and IL-6 (Akiyama et al., 2000)....
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...…also been shown to activate microglia and induce the production of factors, such as nitric oxide (NO), ROS, proinflammatory cytokines (e.g., TNF-a, IL-1b, IL-6), chemokines (e.g., IL-18), and prostaglandins (e.g., PGE2), that promote neuronal death (Akiyama et al., 2000; Kitazawa et al., 2004)....
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...Similarly, signal transduction pathways downstream of these receptors that regulate the activities of the transcription factors NF-kB and AP-1 appear to play general roles in mediating the production of amplifiers and effector molecules, such as cytokines (e.g., TNF-a, IL-1b, and IL-6), ROS, and NO....
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..., PGE2), that promote neuronal death (Akiyama et al., 2000; Kitazawa et al., 2004)....
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...In the presence of IL-6 and TGF-b, the naı̈ve T cells are induced to express retinoic acid receptor-related orphan receptor gt (RORgt) and differentiate into Th17 cells....
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2,471 citations
Cites background from "Inflammation and Alzheimer's diseas..."
...Neuroinflammation is a hallmark of AD brain and is characterized by the presence of activated astrocytes and microglia surrounding amyloid plaques (for review, see Akiyama et al., 2000)....
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2,246 citations
2,094 citations
References
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"Inflammation and Alzheimer's diseas..." refers background in this paper
...It has also been suggested that transformed cell lines are more susceptible to TNFa toxicity than untransformed lines [69]....
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...[69] Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B....
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3,653 citations
"Inflammation and Alzheimer's diseas..." refers background in this paper
...The chemokines constitute a large family of over 50 cytokines that induce chemotaxis, tissue extravasation, and functional modulation of a variety of leukocytes during inflammation [317]....
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3,635 citations