Open AccessDOI
Inflammation and pain in skin and deep tissues
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TLDR
Evaluate the change in sensitivity after inflammation inside and outside the irradiated skin and investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.Abstract:
Ultraviolet-B irradiation model has been used for many years as a translational model since it is well known to induce cutaneous inflammatory pain in both animals and humans. The aim of this study project was to evaluate time course and sensory changes induced by UVB and in particular: 1) evaluate the change in sensitivity after inflammation inside and outside the irradiated skin, 2) investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia, 3) investigate the effect on mechanical hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.read more
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Book Chapter
Wall and Melzack's textbook of pain
TL;DR: The Wall and Melzack's Textbook of Pain is revised under new editorial leadership, and with a host of new, multidisciplinary international contributors.
Journal ArticleDOI
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
Journal ArticleDOI
Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.
TL;DR: In this article, the authors explored the contribution of capsaicin-sensitive nociceptors in the development of mechanical and heat hyperalgesia in humans following ultraviolet-B (UVB) irradiation.
References
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Journal ArticleDOI
Painful and non-painful pressure sensations from human skeletal muscle.
TL;DR: The present data show a marginal contribution of cutaneous afferents to the pressure pain sensation that, however, is relatively more dependent on contributions from deep tissue group III and IV Afferents.
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Increased pressure pain sensibility in fibromyalgia patients is located deep to the skin but not restricted to muscle tissue
Eva Kosek,Jan Ekholm,Per Hansson +2 more
TL;DR: It is demonstrated that pressure‐induced pain sensibility in FM patients is not most pronounced in muscle tissue and does not depend on increased skin sensibility.
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Different effects of strenuous eccentric exercise on the accumulation of neutrophils in muscle in women and men
TL;DR: It is concluded that the sex influences the presence of Tc-99m neutrophils in the exercised muscle following eccentric exercise, and different patterns of DOMS and torque were observed between the sexes after eccentric exercise.
Journal ArticleDOI
Experimentally induced muscle pain induces hypoalgesia in heterotopic deep tissues, but not in homotopic deep tissues
TL;DR: The inhibitory mechanism during muscle pain was shown to be effective for the deep tissue sensibility in healthy subjects and may result in widespread deep hyperalgesia in muscle pain patients.
Journal ArticleDOI
Response properties and descending control of rat dorsal horn neurons with deep receptive fields.
Yu Xian-Min,Siegfried Mense +1 more
TL;DR: The results suggest that in the rat a considerable proportion of dorsal horn cells receives input from deep nociceptors and that this input is controlled by descending pathways in a rather selective way.