Open AccessDOI
Inflammation and pain in skin and deep tissues
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TLDR
Evaluate the change in sensitivity after inflammation inside and outside the irradiated skin and investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.Abstract:
Ultraviolet-B irradiation model has been used for many years as a translational model since it is well known to induce cutaneous inflammatory pain in both animals and humans. The aim of this study project was to evaluate time course and sensory changes induced by UVB and in particular: 1) evaluate the change in sensitivity after inflammation inside and outside the irradiated skin, 2) investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia, 3) investigate the effect on mechanical hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.read more
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Book Chapter
Wall and Melzack's textbook of pain
TL;DR: The Wall and Melzack's Textbook of Pain is revised under new editorial leadership, and with a host of new, multidisciplinary international contributors.
Journal ArticleDOI
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
Journal ArticleDOI
Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.
TL;DR: In this article, the authors explored the contribution of capsaicin-sensitive nociceptors in the development of mechanical and heat hyperalgesia in humans following ultraviolet-B (UVB) irradiation.
References
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Journal ArticleDOI
Weighted needle pinprick sensory thresholds: a simple test of sensory function in diabetic peripheral neuropathy
TL;DR: PPT and thermal thresholds probably give comparable information on small fibre dysfunction in diabetic patients with symptomatic neuropathy and Marstock thermal limen in diabetic Patients with painful neuropathy correlated significantly with PPT determinations.
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Response behaviour of cat dorsal horn neurones receiving input from skeletal muscle and other deep somatic tissues.
U Hoheisel,Siegfried Mense +1 more
TL;DR: Evidence is presented that in dorsal horn cells with deep input not only the mechanical excitability but also the degree of convergence is controlled by descending spinal pathways.
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Substance P and nitric oxide mediate wound healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferation
TL;DR: It is suggested that endogenous SP and NO have a trophic function in wound healing after UV-induced damage of the skin which may be mediated by stimulation of angiogenesis or epidermal cell proliferation.
Journal ArticleDOI
Skin blood flow reduction induced by cigarette smoking: role of vasopressin
TL;DR: There was a significant correlation between the SBF decrease during the first smoking period and the plasma vasopressin levels measured afterwards and it appears that the decrease in SBF induced by smoking is due to enhanced vasopressingin secretion.
Journal ArticleDOI
Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man
TL;DR: It is concluded that the UVB model, as the pinch model, is suitable for establishing antihyperalgesic effects of NSAIDs, but probably not of &kgr;‐receptor agonists, in healthy human volunteers.