Open AccessDOI
Inflammation and pain in skin and deep tissues
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TLDR
Evaluate the change in sensitivity after inflammation inside and outside the irradiated skin and investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.Abstract:
Ultraviolet-B irradiation model has been used for many years as a translational model since it is well known to induce cutaneous inflammatory pain in both animals and humans. The aim of this study project was to evaluate time course and sensory changes induced by UVB and in particular: 1) evaluate the change in sensitivity after inflammation inside and outside the irradiated skin, 2) investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia, 3) investigate the effect on mechanical hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.read more
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Wall and Melzack's textbook of pain
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Journal ArticleDOI
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
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Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.
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References
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Journal ArticleDOI
Characterisation of ultraviolet-B-induced inflammation as a model of hyperalgesia in the rat.
Thomas Bishop,David W. Hewson,Ping K. Yip,M S Fahey,David Dawbarn,Antony R. Young,Stephen B. McMahon +6 more
TL;DR: It is concluded that UVB inflammation produces a dose‐dependent hyperalgesic state sensitive to established analgesics, which suggests thatUVB inflammation in the rat may represent a useful translational tool in the study of pain and the testing of analgesic agents.
Journal ArticleDOI
Experimental pain in human temporal muscle induced by hypertonic saline, potassium and acidity.
Kai Arne Jensen,Michael Norup +1 more
TL;DR: The study aimed at developing a reference model for experimental pain and tenderness in the human temporal muscle by the local injection of hypertonic saline, potassium chloride and acidic phosphate buffer, using isotonic saline as control with positive correlation between the relative occurrence of referred pain and pain intensity.
Journal ArticleDOI
Influence of surface anesthesia on the pressure pain threshold measured with different-sized probes
TL;DR: Results suggest that larger pressure probes can give a better estimation of muscular pain threshold, suggesting that mechanical pain thresholds measured with 1.6 and 15 mm probes reflect the pain threshold of deep tissues, possibly muscle.
Journal ArticleDOI
Ultraviolet‐B induced inflammation of human skin: Characterisation and comparison with traditional models of hyperlagesia
TL;DR: It is suggested that UVB inflammation, at least using moderate doses produces sensory changes primarily by sensitising peripheral pain processing in the relative absence of alterations in central pain processing.
Journal Article
Human experimental pain models in drug development: translational pain research
TL;DR: This work has shown that biomarkers, for example, those related to the central integration of repetitive nociceptive stimuli, can predict efficacy of a given drug in neuropathic pain conditions and can act as translational research providing new possibilities for designing successful clinical trials.