Inflammation and pain in skin and deep tissues

doi:10.5278/VBN.PHD.MED.00015

Home
/
Papers
/
Inflammation and pain in skin and deep tissues

Inflammation and pain in skin and deep tissues

01 Jan 2015-

TL;DR: Evaluate the change in sensitivity after inflammation inside and outside the irradiated skin and investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.

read less

Abstract: Ultraviolet-B irradiation model has been used for many years as a translational model since it is well known to induce cutaneous inflammatory pain in both animals and humans. The aim of this study project was to evaluate time course and sensory changes induced by UVB and in particular: 1) evaluate the change in sensitivity after inflammation inside and outside the irradiated skin, 2) investigate the existence of a mechanism of cumulative effects between cutaneous and deep-tissue hyperalgesia, 3) investigate the effect on mechanical hyperalgesia and allodynia induced by UVB irradiation after application of heat stimuli and sensitization of deep tissues.

...read moreread less

Content maybe subject to copyright Report

Citations

PDF

Open Access

More filters

Book Chapter•

Wall and Melzack's textbook of pain

[...]

Joanna M Zakrzewska, Benjamin C. Lopez

01 Jan 2006

TL;DR: The Wall and Melzack's Textbook of Pain is revised under new editorial leadership, and with a host of new, multidisciplinary international contributors.

...read moreread less

Abstract: WALL AND MELZACK'S TEXTBOOK OF PAIN, revised under new editorial leadership, and with a host of new, multidisciplinary international contributors ...

...read moreread less

527 citations

Journal Article•DOI•

Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo

[...]

Josef Donnerer, Rufina Schuligoi, Rainer Amann, Christoph Stein

01 May 1992-Neuropeptides

TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.

...read moreread less

223 citations

Journal Article•DOI•

Core Topics in Pain.

[...]

A Philip J. Lake

01 Apr 2007-Anesthesiology

19 citations

Journal Article•DOI•

Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.

[...]

Silvia Lo Vecchio¹, Hjalte Holm Andersen¹, Jesper Elberling², Lars Arendt-Nielsen¹•Institutions (2)

Aalborg University¹, Copenhagen University Hospital²

24 Jul 2021-Experimental Brain Research

TL;DR: In this article, the authors explored the contribution of capsaicin-sensitive nociceptors in the development of mechanical and heat hyperalgesia in humans following ultraviolet-B (UVB) irradiation.

...read moreread less

Abstract: Subpopulations of primary nociceptors (C- and Aδ-fibers), express the TRPV1 receptor for heat and capsaicin. During cutaneous inflammation, these afferents may become sensitized, leading to primary hyperalgesia. It is known that TRPV1+ nociceptors are involved in heat hyperalgesia; however, their involvement in mechanical hyperalgesia is unclear. This study explored the contribution of capsaicin-sensitive nociceptors in the development of mechanical and heat hyperalgesia in humans following ultraviolet-B (UVB) irradiation. Skin areas in 18 healthy volunteers were randomized to treatment with 8% capsaicin/vehicle patches for 24 h. After patches removal, one capsaicin-treated area and one vehicle area were irradiated with 2xMED (minimal erythema dose) of UVB. 1, 3 and 7 days post-UVB exposure, tests were performed to evaluate the development of UVB-induced cutaneous hyperalgesia: thermal detection and pain thresholds, pain sensitivity to supra-threshold heat stimuli, mechanical pain threshold and sensitivity, touch pleasantness, trans-epidermal water loss (TEWL), inflammatory response, pigmentation and micro-vascular reactivity. Capsaicin pre-treatment, in the UVB-irradiated area (Capsaicin + UVB area), increased heat pain thresholds (P 0.2). No effects of capsaicin were reported on touch pleasantness (P = 1), TEWL (P = 0.31), inflammatory response and pigmentation (P > 0.3) or micro-vascular reactivity (P > 0.8) in response to the UVB irradiation. 8% capsaicin ablation predominantly defunctionalizes TRPV1+-expressing cutaneous nociceptors responsible for heat pain transduction, suggesting that sensitization of these fibers is required for development of heat hyperalgesia following cutaneous UVB-induced inflammation but they are likely only partially necessary for the establishment of robust primary mechanical hyperalgesia.

...read moreread less

1 citations

References

PDF

Open Access

More filters

Journal Article•DOI•

Responses of Single Dorsal Cord Cells to Peripheral Cutaneous Unmyelinated Fibres

[...]

Lorne M. Mendell¹, Patrick D. Wall¹•Institutions (1)

Massachusetts Institute of Technology¹

03 Apr 1965-Nature

TL;DR: An investigation of the response of cells in the dorsolateral tract of the cat to C fibres was carried out, finding that an afferent volley in the unmyelinated fibres led to a positive dorsal root potential as opposed to the well-known negative dorsal potential which is elicited by the large myelination fibres.

...read moreread less

Abstract: IN the dorsal part of the dorsal horn there is a lamina of cells which respond to cutaneous stimulation and send their axons into the dorsolateral tract. In previous investigations1 it was apparent that many different types of A fibres converged on these cells. It is, therefore, interesting to see whether C fibres also affect their firing. In a recent investigation2 it was found that an afferent volley in the unmyelinated fibres led to a positive dorsal root potential as opposed to the well-known negative dorsal potential which is elicited by the large myelinated fibres. It was suggested that C fibres led to presynaptic hyperpolarization which would produce facilitation as contrasted with the presynaptic inhibitory effects of the A fibres. An investigation of the ventral root reflex (VRR, ref. 2) showed no late component which could be attributed to C fibres; however, a tetanus in the C's was found to potentiate the VRR elicited by the A fibres in the same peripheral nerve. It was also known that a large stimulus to a peripheral nerve led to late discharges in various midbrain and forebrain structures3. With these factors in mind an investigation of the response of cells in the dorsolateral tract of the cat to C fibres was carried out.

...read moreread less

556 citations

"Inflammation and pain in skin and d..." refers background in this paper

...This is a mechanism where the sensitivity of the neurons in the dorsal horn to C-fibre input can be intensified by repetitive stimulation (Hayashi et al., 2013; Mendell and Wall 1965)....
[...]

Journal Article•DOI•

Mechanisms of inflammatory pain

[...]

Bruce L. Kidd, Laszlo Urban¹•Institutions (1)

Novartis¹

01 Jul 2001-BJA: British Journal of Anaesthesia

554 citations

"Inflammation and pain in skin and d..." refers background in this paper

...and its transmission to the brain through periphera l and central neurons (Holdcroft and Jaggar 2005; Kidd and Urban 2001; Woolf 1983)....
[...]
...A large number of these mediators such as nitric oxide, histamine, bradykinin, prostaglandins, cytokines, 15 and NGF are involved in the sensitization of the peripheral nociceptors located on the sensory neurons innervating the region of the irradiation (Dray 1995; Kidd and Urban 2001)....
[...]
...The process of nociception refers to the recognition of a noxious stimulus from a nociceptor and its transmission to the brain through peripheral and central neurons (Holdcroft and Jaggar 2005; Kidd and Urban 2001; Woolf 1983)....
[...]
...15 and NGF are involved in the sensitization of the pe ripheral nociceptors located on the sensory neurons innervating the region of the irradiation ( Dray 1995; Kidd and Urban 2001)....
[...]

Journal Article•DOI•

Ultraviolet light induced injury: immunological and inflammatory effects.

[...]

GJ Clydesdale¹, GW Dandie¹, HK Muller¹•Institutions (1)

University of Tasmania¹

01 Dec 2001-Immunology and Cell Biology

TL;DR: An overview of the acute inflammatory and immunological events associated with cutaneous UV exposure is given, which are important to consider before dealing with the complex interactions that occur with chronic UV exposure, leading to photocarcinogenesis.

...read moreread less

Abstract: This article reviews many of the complex events that occur after cutaneous ultraviolet (UV) exposure. The inflammatory changes of acute exposure of the skin include erythema (sunburn), the production of inflammatory mediators, alteration of vascular responses and an inflammatory cell infiltrate. Damage to proteins and DNA accumulates within skin cells and characteristic morphological changes occur in keratinocytes and other skin cells. When a cell becomes damaged irreparably by UV exposure, cell death follows via apoptotic mechanisms. Alterations in cutaneous and systemic immunity occur as a result of the UV-induced inflammation and damage, including changes in the production of cytokines by keratinocytes and other skin-associated cells, alteration of adhesion molecule expression and the loss of APC function within the skin. These changes lead to the generation of suppressor T cells, the induction of antigen-specific immunosuppression and a lowering of cell-mediated immunity. These events impair the immune system's capacity to reject highly antigenic skin cancers. This review gives an overview of the acute inflammatory and immunological events associated with cutaneous UV exposure, which are important to consider before dealing with the complex interactions that occur with chronic UV exposure, leading to photocarcinogenesis.

...read moreread less

544 citations

"Inflammation and pain in skin and d..." refers background in this paper

...Recent studies have found an increase in production of nitric oxide (NO) by keratinocytes following UVB irradiation, showing that NO may also have an important role in inducing vasodilatation and erythema after irradiation (Clydesdale et al., 2001)....
[...]
...important role in inducing vasodilatation and eryth ema after irradiation (Clydesdale et al., 2001)....
[...]

Journal Article•DOI•

Nerve growth factor and nociception

[...]

Gary R. Lewin¹, Lorne M. Mendell¹•Institutions (1)

Stony Brook University¹

01 Sep 1993-Trends in Neurosciences

TL;DR: Despite apparent changes in NGF's mode of action as the animal matures, it always interacts specifically with nociceptive sensory neurons and here it may serve as a link between inflammation and hyperalgesia.

...read moreread less

538 citations

"Inflammation and pain in skin and d..." refers background in this paper

...As a direct consequence of the inflammatory process, the NGF production increases in the periphery and, in case of persistent inflammation, it can be transported backward from the periphery toward the dorsal root ganglion (Goedert et al., 1981; Lewin and Mendell 1993)....
[...]

Book Chapter•

Wall and Melzack's textbook of pain

[...]

Joanna M Zakrzewska, Benjamin C. Lopez

01 Jan 2006

TL;DR: The Wall and Melzack's Textbook of Pain is revised under new editorial leadership, and with a host of new, multidisciplinary international contributors.

...read moreread less

Abstract: WALL AND MELZACK'S TEXTBOOK OF PAIN, revised under new editorial leadership, and with a host of new, multidisciplinary international contributors ...

...read moreread less

527 citations

"Inflammation and pain in skin and d..." refers background in this paper

...The term primary hyperalgesia indicates an increase in nociceptor responsiveness in the site of injury, while secondary hyperalgesia indicates an increase in responsiveness to normal painful stimuli in the undamaged area surrounding the injury (Fig 1), (Ali et al., 1996; Meyer et al., 2006)....
[...]
...increase in nociceptor responsiveness in the site o f injury, while secondary hyperalgesia indicates an increase in responsiveness to normal painful sti muli in the undamaged area surrounding the injury (Fig 1), (Ali et al., 1996; Meyer et al., 2006)....
[...]