Inflammation and postinfarct remodeling: Overexpression of IκB prevents ventricular dilation via increasing TIMP levels
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Cites result from "Inflammation and postinfarct remode..."
...Comparable results have been obtained using a strategy of myocardial overexpression of IkappaBalpha by adenovirusmediated transfection in rats (107)....
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Cites background from "Inflammation and postinfarct remode..."
...…of this, limited left ventricular dilation and reduced expression of MMP-2 and MMP-9 was observed in rats overexpressing the endogenous inhibitor (IjB) of the NF-jB transcription factor (which regulates MMP-2 and 9 gene transcription) following coronary artery ligation (Trescher et al. 2006)....
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References
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"Inflammation and postinfarct remode..." refers background or methods in this paper
...Blocking NF-nB activity in experimental models of acute myocardial ischemia and myocarditis reduced the expression of adhesion molecules and inflammatory cytokines and consequently preserved cardiac function [11–14] .I n addition to orchestrating the inflammatory cascade post-MI, NFnB directly regulates the transcription of MMP-1, MMP-2, MMP-3, MMP-9 and MMP-13 and TIMP-1 [15, 16 ]....
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...In the present study, we chose MMP-2 and -9 since they play a central role in cardiac remodeling, and their transcription is directly regulated by NF-nB [15, 16 ]....
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323 citations
"Inflammation and postinfarct remode..." refers background in this paper
...Inflammatory factors like TNF-a and IL-1h lead to the activation of MMPs as could be shown both in vivo and in vitro [5,6, 29 ]....
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303 citations
"Inflammation and postinfarct remode..." refers background in this paper
...The importance of TIMP-4 abundance not only in acute ischemia but for matrix turnover in postinfarct remodeling was reported in a rat model of MI [ 40 ]....
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273 citations
"Inflammation and postinfarct remode..." refers background in this paper
...In contrast, recovery of cardiac structure and function in failing hearts is accompanied by a restoration of TIMP-3 levels [36]....
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