Journal ArticleDOI
Inflammation, atherosclerosis, and coronary artery disease.
Reads0
Chats0
About:
This article is published in The New England Journal of Medicine.The article was published on 2005-07-28. It has received 1982 citations till now. The article focuses on the topics: Coronary artery disease & Myocardial infarction.read more
Citations
More filters
Journal ArticleDOI
Development and Validation of Improved Algorithms for the Assessment of Global Cardiovascular Risk in Women: The Reynolds Risk Score
TL;DR: 2 clinical algorithms for global cardiovascular risk prediction that reclassified 40% to 50% of women at intermediate risk into higher- or lower-risk categories are developed and demonstrated highly improved accuracy.
Journal ArticleDOI
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.
Yiannis S. Chatzizisis,Ahmet U. Coskun,Michael Jonas,Elazer R. Edelman,Elazer R. Edelman,Charles L. Feldman,Peter Stone +6 more
TL;DR: The molecular, cellular, and vascular processes supporting the role of low ESS in the natural history of coronary atherosclerosis and vascular remodeling are explored and likely mechanisms concerning the different natural history trajectories of individual coronary lesions are indicated.
Journal ArticleDOI
Role of cholesterol and lipid organization in disease.
Frederick R. Maxfield,Ira Tabas +1 more
TL;DR: Significant recent progress has enhanced the understanding of the molecular and cellular basis of lipid-associated disorders such as Tangier disease, Niemann–Pick disease type C and atherosclerosis.
Journal ArticleDOI
Low-Dose Aspirin for the Prevention of Atherothrombosis
TL;DR: This review considers the role of low-dose aspirin for the prevention of atherothrombosis as well as clinical and epidemiologic studies of aspirin as an antiplatelet agent, with special emphasis on the benefits and risks in different patient populations.
Journal ArticleDOI
Human oral, gut, and plaque microbiota in patients with atherosclerosis
Omry Koren,Aymé Spor,Jenny Felin,Frida Fåk,Jesse Stombaugh,Valentina Tremaroli,Carl Johan Behre,Rob Knight,Björn Fagerberg,Ruth E. Ley,Fredrik Bäckhed +10 more
TL;DR: The findings suggest that bacteria from the oral cavity, and perhaps even the gut, may correlate with disease markers of atherosclerosis, and several bacterial taxa in the Oral cavity and the gut correlated with plasma cholesterol levels.
References
More filters
Journal ArticleDOI
Inflammation, Atherosclerosis, and Coronary Artery Disease
TL;DR: The evidence is recounted that atherosclerosis, the main cause of CAD, is an inflammatory disease in which immune mechanisms interact with metabolic risk factors to initiate, propagate, and activate lesions in the arterial tree.
Journal ArticleDOI
Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
Journal ArticleDOI
The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
TL;DR: The results indicate that the anti-inflammatory properties of aspirin and salicylate are mediated in part by their specific inhibition of IKK-β, thereby preventing activation by NF-κB of genes involved in the pathogenesis of the inflammatory response.
Journal ArticleDOI
Prognostic Value of Myeloperoxidase in Patients with Chest Pain
Marie Luise Brennan,Marc S. Penn,Frederick Van Lente,Vijay Nambi,Mehdi H. Shishehbor,Ronnier J. Aviles,Marlene Goormastic,Michael Pepoy,Ellen McErlean,Eric J. Topol,Steven E. Nissen,Stanley L. Hazen +11 more
TL;DR: Myeloperoxidase levels, in contrast to troponin T, creatine kinase MB isoform, and C-reactive protein levels, identified patients at risk for cardiac events in the absence of myocardial necrosis, highlighting its potential usefulness for risk stratification among patients who present with chest pain.
Journal ArticleDOI
Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes.
TL;DR: Results support a particular role for the myeloperoxidase-expressing macrophages in atheroma complication and the acute coronary syndromes and identify granulocytemacrophage colony-stimulating factor as an endogenous regulator of macrophage myelopersidase expression in human atherosclerosis.
Related Papers (5)
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II.
Morteza Naghavi,Peter Libby,Erling Falk,S. Ward Casscells,S. Ward Casscells,Silvio H. Litovsky,Silvio H. Litovsky,John A. Rumberger,Juan J. Badimon,Christodoulos Stefanadis,Pedro R. Moreno,Gerard Pasterkamp,Zahi A. Fayad,Peter Stone,Sergio Waxman,Paolo Raggi,Mohammad Madjid,Mohammad Madjid,Alireza Zarrabi,Alireza Zarrabi,Allen P. Burke,Chun Yuan,Peter J. Fitzgerald,David S. Siscovick,Chris L. de Korte,Masanori Aikawa,K.E. Juhani Airaksinen,Gerd Assmann,Christoph R. Becker,James H. Chesebro,Andrew Farb,Zorina S. Galis,Christopher L. Jackson,Ik-Kyung Jang,Wolfgang Koenig,Robert A. Lodder,Keith L. March,Jasenka Demirovic,Mohamad Navab,Silvia G. Priori,Mark D. Rekhter,Raymond D. Bahr,Scott M. Grundy,Roxana Mehran,Antonio Colombo,Eric Boerwinkle,Christie M. Ballantyne,William Insull,Robert S. Schwartz,Robert A. Vogel,Patrick W. Serruys,Göran K. Hansson,David P. Faxon,Sanjay Kaul,Helmut Drexler,Philip Greenland,James E. Muller,Renu Virmani,Renu Virmani,Paul M. Ridker,Douglas P. Zipes,Prediman K. Shah,James T. Willerson,James T. Willerson +63 more