Influence of immunoglobulin G and immunoglobulin A on erythrocyte aggregation: a comparative study
TL;DR: The present study shows that the aggregation index could further be used as a rapid supplementary test for the initial investigation and therapeutic response of hyperglobulinemic patients.
Abstract: Analysis of the aggregation of erythrocytes as measured by aggregation index in blood samples obtained from patients with elevated levels of immunoglobulin G (Ig G) and immunoglobulin A (Ig A) is carried out. The aggregation index (AI) and plasma viscosity (PV) are correlated with the total protein, albumin, Ig G, Ig A and Ig M and total globulin concentrations of samples and are compared with that of normal blood. The results show that the AI depends more on the monoclonal globulin concentrations and this dependence is more for Ig A than that for Ig G. There is no correlation between either AI and IgM in both these samples. The present study shows that the aggregation index could further be used as a rapid supplementary test for the initial investigation and therapeutic response of hyperglobulinemic patients.
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01 Jan 2007
TL;DR: The results demonstrate the ability of wavelets to precisely differentiate variations in degree of aggregation and their intercellular bonding and the aggregation size indices are found to be similar and consistent for a given aggregate for all wavelet functions.
Abstract: Aggregation of red blood cells which manifests in the form of rouleaux is a major determinant of flow behavior of blood in both micro and macro circulation. Any alteration in the normal behavior is found to be a critical factor in plugging of arterioles and venules forming irreversible clumps. In this work, the aggregation behavior of red blood cells is analyzed using Wavelet transforms. The artificially induced red cell aggregate images obtained from normal adult volunteers are used for the study. An arbitrary aggregation size index is derived using four different wavelet functions. The results demonstrate the ability of wavelets to precisely differentiate variations in degree of aggregation and their intercellular bonding. Also the aggregation size indices are found to be similar and consistent for a given aggregate for all wavelet functions. As the association and dissociation of red cells and the bonding strength during cluster formation are direct indicators of altered flow behavior of red cells in micro-vessels and large arteries such analysis seems to be clinically relevant. The methodology, algorithm and observations based on Wavelet transforms are discussed in detail.
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Cites methods from "Influence of immunoglobulin G and i..."
...Blood samples for the study are obtained from healthy, adult volunteers (N=10) at Klinicum der RWTH, Aachen, Germany as described elsewhere [18, 20]....
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TL;DR: The hyperviscosity syndrome commonly includes mucous membrane bleeding, retinopathy and loss of vision, and neurological disorders associated with elevated serum viscosity, and is frequently seen in patients with macroglobulinemia, with or without demonstrable lymphoma, but only rarely with multiple myeloma.
Abstract: The hyperviscosity syndrome commonly includes mucous membrane bleeding, retinopathy and loss of vision, and neurological disorders associated with elevated serum viscosity. These changes can be lethal. Hyperviscosity, however, can be relieved by adequate plasmapheresis, and recognition of the hyperviscosity syndrome is important for the institution of the proper therapy. The association of elevated serum viscosity with marked hypergammaglobulinemia has been recognized for more than 30 years. Between 1932 and 1937 Reismann,1Magnus-Levy,2and Albers3reported increased serum viscosity in several patients with multiple myeloma. In 1944 Waldenstrom described an elevated serum viscosity in patients with macroglobulinemia.4These findings have been extended in recent years by the delineation of a group of clinical symptoms attributable to increased viscosity of the blood.5-10 The hyperviscosity syndrome is frequently seen in patients with macroglobulinemia, with or without demonstrable lymphoma, but only rarely with multiple myeloma. Manifestations of the hyperviscosity
235 citations
TL;DR: The changes in viscosity that occur after IVIG therapy can impair blood flow, and in patients at risk of cardiovascular and thromboembolic events they might be sufficient to produce myocardial infarction or stroke.
183 citations
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01 May 1991TL;DR: A history of the Chronic Leukemias, epidemiology and Epidemiology of Chronic Myeloid Leukemia, and support for patients with Leukemia.
Abstract: A History of the Chronic Leukemias -- Etiology and Epidemiology of Chronic Myeloid Leukemia -- Pathology of the Chronic Myeloid Leukemias -- Molecular Biology and Cytogenetics of Chronic Myeloid Leukemia -- Diagnosis and Treatment of Chronic Myeloid Leukemia -- Etiology and Epidemiology of CLL -- Histopathology, Morphology, and Immunophenotyping of CLL -- Molecular Biology and Cytogenetics of Chronic Lymphocytic Leukemia -- Treatment of Chronic Lymphocytic Leukemia and Related Disorders -- Hairy Cell Leukemia -- The Pathogenesis, Diagnosis, and Treatment of Polycythemia Vera -- Diagnosis and Treatment of Essential Thrombocythemia and Primary Myelofibrosis -- History of Acute Leukemia -- The Etiology of Acute Leukemia -- Epidemiology and Hereditary Aspects of Acute Leukemia -- Classification of the Acute Leukemias: Cytochemical and Morphologic Considerations -- Immunobiology of Acute Leukemia -- Cytogenetics of Acute Leukemia -- Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia -- Diagnosis and Treatment of Adult Acute Lymphoblastic Leukemia -- Diagnosis and Treatment of Childhood Acute Myeloid Leukemia -- Diagnosis and Treatment of Adult Acute Myeloid Leukemia Other Than Acute Promyelocytic Leukemia -- Acute Promyelocytic Leukemia -- Therapy-Related Acute Myelogenous Leukemia -- The Myelodysplastic Syndromes -- History of Multiple Myeloma -- Cytokines and Signal Transduction in Multiple Myeloma -- Epidemiology of Multiple Myeloma -- Immunoglobulins and Laboratory Recognition of Monoclonal Proteins -- Cytogenetic Abnormalities in MGUS and Myeloma -- Molecular Genetics of Myeloma -- Prognosis and Staging of Multiple Myeloma -- Diagnosis and Treatment of Multiple Myeloma -- Complications and Special Presentations of Plasma Cell Myeloma -- Waldenstrom’s Macroglobulinemia -- Heavy-Chain Disease -- Diagnosis and Therapy of Immunoglobulin Light Chain Amyloidosis (AL Amyloidosis) -- Monoclonal Gammopathy of Undetermined Significance -- Historical Landmarks in the Understanding of the Lymphomas -- Genetics in Lymphomagenesis -- Epidemiology and Hereditary Aspects of Hodgkin and Non-Hodgkin Lymphomas -- Pathology of Non-Hodgkin and Hodgkin Lymphomas -- Immunology of the Lymphomas -- Cytogenetics of Lymphomas -- Diagnosis and Treatment of Hodgkin’s Lymphoma -- Radiotherapeutic Management of Lymphomas -- Diagnosis and Treatment of Non-Hodgkin’s Lymphoma of Adults -- Non-Hodgkin Lymphoma of Childhood -- Lymphoma in Other Diseases -- Supportive Care for Patients with Leukemia: A Historical Perspective -- Prevention of Infections in Patients with Hematological Malignancies -- Evaluation and Management of Bacterial and Fungal Infections Occurring in Patients with a Hematological Malignancy: A 2011 Update -- Viral Infections in Patients with Hematological Malignancies -- Therapeutic Cytapheresis, Plasmapheresis, and Plasma Exchange in Neoplastic Diseases of the Blood -- Red Cell Transfusions in Patients with Hematologic Malignancies -- Platelet and Granulocyte Transfusion -- Alternative Sources of Hematopoietic Stem Cells and Their Clinical Applications -- HLA Typing in Support of Hematopoietic Cell Transplantation from Unrelated Donors -- Special Care of Blood and Marrow Stem Transplant Patients -- Hematopoietic Growth Factors in the Supportive Care and Treatment of Patients with Hematologic Neoplasms -- Bleeding and Thrombosis in Hematologic Neoplasia -- Psychological Aspects of Hematological Neoplasms.-.
158 citations