Journal ArticleDOI
Influenza virus resistance to neuraminidase inhibitors.
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TLDR
The mechanism of action, pharmacokinetics and clinical indications of neuraminidase inhibitors (NAIs) with an emphasis on the emergence of antiviral drug resistance are reviewed.About:
This article is published in Antiviral Research.The article was published on 2013-05-01. It has received 278 citations till now. The article focuses on the topics: Peramivir & Zanamivir.read more
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Antiviral Natural Products and Herbal Medicines
TL;DR: In this mini-review, a summary of the antiviral effects reported for several natural products and herbal medicines is summarized.
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Continuing challenges in influenza
TL;DR: The challenges facing influenza scientists and veterinary and human public health officials are reviewed and the exciting possibility of achieving the ultimate goal of controlling influenza's ability to change its antigenicity is discussed.
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Broad-spectrum antivirals against viral fusion
TL;DR: The mechanisms responsible for the fusion between virus and cell membranes are discussed and how broad-spectrum antivirals target this process to prevent virus entry are explored.
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The role of viral, host, and secondary bacterial factors in influenza pathogenesis.
TL;DR: Understanding the molecular mechanisms by which influenza and secondary bacterial infections, coupled with the role of host risk factors, contribute to enhanced morbidity and mortality is essential to develop better therapeutic strategies to treat severe influenza.
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Antiviral strategies against influenza virus: towards new therapeutic approaches.
TL;DR: An overview of novel strategies targeting the virus and/or the host cell for counteracting influenza virus infection and several new classes of antiviral agents targeting viral replication mechanisms or cellular proteins/processes are under development.
References
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Journal ArticleDOI
Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection
de Jong,Tran Tt,Truong Hk,Vo Mh,Gavin J. D. Smith,Nguyen Vc,Bach Vc,Phan Tq,Do Qh,Yi Guan,Joseph Malik Sriyal Peiris,Tran Th,Jeremy Farrar +12 more
TL;DR: It is suggested that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents.
Journal ArticleDOI
Resistant influenza A viruses in children treated with oseltamivir: descriptive study
Maki Kiso,Keiko Mitamura,Yuko Sakai-Tagawa,Kyoko Shiraishi,Chiharu Kawakami,Kazuhiro Kimura,Frederick G. Hayden,Norio Sugaya,Yoshihiro Kawaoka,Yoshihiro Kawaoka +9 more
TL;DR: Sensitivity testing to oseltamivir carboxylate revealed that the neuraminidases of viruses that have an Arg292Lys, Glu119Val, or Asn294Ser mutation were about 10(4)-10(5)-fold, 500-fold, or 300-fold more resistant than their pretreatment neuraminIDases, respectively.
Journal ArticleDOI
Structure of the catalytic and antigenic sites in influenza virus neuraminidase
TL;DR: The catalytic sites of influenza virus neuraminidase are located on the upper corners of the box-shaped tetramer that forms the head of the molecule, and determinants form a nearly-continuous surface across the top of the monomer encircling the catalytic site.
Journal ArticleDOI
Avian flu: isolation of drug-resistant H5N1 virus.
Q. Mai Le,Maki Kiso,Kazuhiko Someya,Yuko T. Sakai,T. Hien Nguyen,Khan H. L. Nguyen,N. Dinh Pham,Ha H. Ngyen,Shinya Yamada,Yukiko Muramoto,Taisuke Horimoto,Ayato Takada,Hideo Goto,Takashi Suzuki,Yasuo Suzuki,Yoshihiro Kawaoka +15 more
TL;DR: The isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza is reported.
Journal ArticleDOI
Oral oseltamivir treatment of influenza in children.
Richard J. Whitley,Frederick G Hayden,Keith S. Reisinger,Nancy L. Young,Regina Dutkowski,David Ipe,Roger G. Mills,Penelope Ward +7 more
TL;DR: Oseltamivir treatment did not affect the influenza-specific antibody response and is an efficacious and well-tolerated therapy for influenza in children when given within 48 h of onset of illness.
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Rational design of potent sialidase-based inhibitors of influenza virus replication.
Mark von Itzstein,Wen-Yang Wu,Gaik B. Kok,Michael S. Pegg,Jeffrey Clifford Dyason,Betty Jin,Tho Van Phan,Mark L. Smythe,Hume Forrest White,Hume Forrest White,Stuart W. Oliver,Peter M. Colman,Joseph N. Varghese,D. Michael Ryan,Jacqueline M. Woods,Richard C. Bethell,Vanessa J. Hotham,Janet M. Cameron,Charles R. Penn +18 more