Infra-red absorption of heteroaromatic, five-membered, monocyclic nuclei—III: Isoxazoles
01 Jan 1961-Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (Elsevier)-Vol. 17, Iss: 3, pp 238-247
TL;DR: In this paper, the infra-red spectra of thirty-four isoxazoles were recorded and discussed, and assignments for the characteristic ring bands were suggested for the ring bands.
About: This article is published in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.The article was published on 1961-01-01. It has received 56 citations till now. The article focuses on the topics: Ring (chemistry) & Isoxazole.
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TL;DR: The extensive investigation of the biological activity of organic compounds reveals active compounds in the isoxazole series.
Abstract: Publisher Summary This chapter reviews new investigations in the field of synthetic isoxazoles. Isoxazoles possess the properties of the aromatic system. The syntheses of isoxazole derivatives involving formation of the 1–5 and 2–3 bonds of the isoxazole ring, as well as formation of the 1–5 and 3–4 bonds of the ring are described in the chapter. The structure and physicochemical properties of isoxazole derivatives is also described. The reactions of isoxazole derivatives with the retention of the heterocyclic nucleus comprise electrophilic substitution reactions, nucleophillic substitution reactions, substitution in the side chain of isoxazoles, grignard synthesis, and condensation involving activated methyl groups of methyl isoxazoles. Isoxazole derivatives involve substances with analgesic and local anaesthetic activity. The action of oxidizing agents of isoxazoles and isoxazolines are discussed in the chapter. The extensive investigation of the biological activity of organic compounds reveals active compounds in the isoxazole series.
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63 citations
TL;DR: The structure of the reaction product of 2,4,6-triphenylpyrylium (II) with hydrazine is different and will be discussed in a later report.
47 citations
TL;DR: A number of new solvates containing isoxazole as the ligand are reported, viz. [M(isoxazoles) 6 ](BF 4 ) 2 (M is Mn, Fe, Co, Ni, Zn and Cd) as mentioned in this paper.
42 citations
TL;DR: In this article, the infra-red and Raman spectra of oxazole and thiazole have been measured in different conditions in order to get definite evidence for a complete assignment of the normal vibrations of these ring compounds.
41 citations
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173 citations
TL;DR: In this paper, the bands characteristic of the alkyl groups in 29 methyl, 27 ethyl, 13 n-propyl, 7 ipropyl and 6 s-butyl esters are recorded and discussed.
46 citations
TL;DR: In this article, all types of amino- and acetamido-isoxazoles exist predominantly as such Ultra-violet spectroscopy indicates that 3- and 5-amino-is oxazoles are protonated at the ring nitrogen atom, but the 4amino analogues on the amino group Basicities of these compounds are recorded
37 citations