Inherited haemoglobin disorders: an increasing global health problem.
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...Regulatory Variation of Globin Genes The thalassemias are the most common Mendelian diseases of humans and constitute a major global health problem (Weatherall and Clegg 2001)....
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...The thalassemias are the most common Mendelian diseases of humans and constitute a major global health problem (Weatherall and Clegg 2001)....
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"Inherited haemoglobin disorders: an..." refers background in this paper
...There is also evidence that the frequency of painful vaso-occlusive episodes can be reduced by the administration of hydroxyurea ( 27 ), although it is still uncertain Table 1. Global summary of approximate numbers of annual births of babies with severe haemoglobin disorders (modified from ref....
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"Inherited haemoglobin disorders: an..." refers background in this paper
...There have also been advances in the control of stroke by the use of long-term transfusion regimens ( 25 ), and with an increased understanding of the mechanisms of pulmonary and splenic sequestration crises, and the judicious use of exchange or top-up transfusion, the management of these life-threatening complication is improving (26)....
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"Inherited haemoglobin disorders: an..." refers background in this paper
...The clinical features of sickle-cell disorders reflect the propensity of the red cells to assume a sickled configuration when blood is oxygenated ( 6 , 7), leading to a shortened red-cell survival and a tendency to vaso-occlusion....
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