Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
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..., 2005), which in T cells may enhance memory T cell formation and anti-tumor responses (Sukumar et al., 2013), we considered a direct effect of L-arginine on protein functions....
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...…to increase lifespan of lower eukaryotes (Tissenbaum and Guarente, 2001) and reduce glycolytic activity (Rodgers et al., 2005), which in T cells may enhance memory T cell formation and anti-tumor responses (Sukumar et al., 2013), we considered a direct effect of L-arginine on protein functions....
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...Repurposing the knowledge gained from such studies, boosting oxidative capacity and efficiency through enforcement of mitochondrial fusion or dampening glycolysis with 2-DG, extends the survival and antitumor function of CD8 T cells in models of adoptive cell therapy (Buck et al., 2016; Sukumar et al., 2013)....
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...formation of resting memory T cell populations, potentiates effector T cell survival and functional capacity against tumors used in adoptive cell therapy (Buck et al., 2016; Sukumar et al., 2013)....
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...…boosting mitochondrial FAO and oxidative phosphorylation (OXPHOS), metabolic pathways that favor the formation of resting memory T cell populations, potentiates effector T cell survival and functional capacity against tumors used in adoptive cell therapy (Buck et al., 2016; Sukumar et al., 2013)....
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...…the knowledge gained from such studies, boosting oxidative capacity and efficiency through enforcement of mitochondrial fusion or dampening glycolysis with 2-DG, extends the survival and antitumor function of CD8 T cells in models of adoptive cell therapy (Buck et al., 2016; Sukumar et al., 2013)....
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669 citations
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Cites methods from "Inhibiting glycolytic metabolism en..."
...Glucose Uptake by Flow Cytometry Formeasuring glucoseuptake inT cells,weused2-NBDG (2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose, purchased from Cayman Chemicals), based upon a previously published protocol (Sukumar et al., 2013)....
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References
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"Inhibiting glycolytic metabolism en..." refers background in this paper
...antiviral (6) responses compared with more-differentiated Tems and Teffs, due to increased proliferative and survival capacities....
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"Inhibiting glycolytic metabolism en..." refers background or methods in this paper
...However, low doses of 2DG have been used to address the role of glycolysis in directing the fate decision of CD4+ Th17 cells versus Foxp3+ Tregs (37, 38)....
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...tion among effector cell subsets, such as Th1, Th2, and Th17, but were not observed during the generation of Tregs, which instead displayed elevated rates of lipid oxidation (37, 38)....
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