Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin
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Cites background from "Inhibition of apoptotic Bax translo..."
...The ubiquitin E3 ligase for the pro-apoptotic factor Bax is reported to be parkin (Charan et al., 2014; Johnson et al., 2012)....
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References
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"Inhibition of apoptotic Bax translo..." refers background in this paper
...Loss-of-function mutations in the ubiquitin E3 ligase parkin are the most common cause of autosomal recessive Parkinson’s disease (PD).(1) Multiple functions have been ascribed to parkin, most notably the inhibition of apoptosis and the induction of autophagic mitochondrial turnover (mitophagy)....
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3,413 citations
"Inhibition of apoptotic Bax translo..." refers background in this paper
...Multiple functions have been ascribed to parkin, most notably the inhibition of apoptosis and the induction of autophagic mitochondrial turnover (mitophagy).(8,9) However, the relative scale of these effects mediated by endogenous parkin and whether these processes can occur concomitantly or are mutually exclusive,...
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...Mitophagy has been well-documented by numerous groups in several immortalized cell lines overexpressing parkin.(8,62) However, the nature of this process in neurons, which express endogenous parkin, has been somewhat controversial....
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2,404 citations
"Inhibition of apoptotic Bax translo..." refers background in this paper
...Multiple functions have been ascribed to parkin, most notably the inhibition of apoptosis and the induction of autophagic mitochondrial turnover (mitophagy).(8,9) However, the relative scale of these effects mediated by endogenous parkin and whether these processes can occur concomitantly or are mutually exclusive,...
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1,876 citations
1,622 citations