Journal ArticleDOI
Inhibition of GPX4 or mTOR overcomes resistance to Lapatinib via promoting ferroptosis in NSCLC cells.
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TLDR
In this paper, the role of Glutathione peroxidase 4 (GPX4) and mammalian target of rapamycin (mTOR) in regulation of lung cancer cells response to Lapatinib (Lap).About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2021-06-20. It has received 30 citations till now. The article focuses on the topics: Lapatinib & Epidermal growth factor receptor.read more
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System Xc −/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
TL;DR: This review aims to present the current understanding of the mechanism of ferroptosis based on the System Xc −/GSH/GPX4 axis in the treatment of drug-resistant solid tumors.
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SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer
TL;DR: In this paper, SIRT6 silencing overcomes sorafenib resistance by promoting ferroptosis, which is a novel form of cell death, in gastric cancer.
Journal ArticleDOI
CircDTL Functions as an Oncogene and Regulates Both Apoptosis and Ferroptosis in Non-small Cell Lung Cancer Cells.
TL;DR: In this article, the authors investigated the role of circRNA in the tumorigenesis of non-small cell lung cancer (NSCLC) using RT-PCR and showed that circDTL upregulated and acted as an oncogene in NSCLC cells.
Journal ArticleDOI
Regulatory pathways and drugs associated with ferroptosis in tumors
Danfeng Wang,Le Tang,Yijie Zhang,Guili Ge,Xianjie Jiang,Yongzhen Mo,Pan Wu,Xiangying Deng,Lvyuan Li,Sicheng Zuo,Qijia Yan,Shanshan Zhang,Fuyan Wang,Lei Shi,Xiayu Li,Bo Xiang,Ming Zhou,Qianjin Liao,Can Guo,Zhaoyang Zeng,Wei Xiong,Zhaojian Gong +21 more
TL;DR: In this paper , the authors reviewed the latest studies on the regulation of ferroptosis in tumor cells and introduced the tumor-related signaling pathways of the FerroPTosis process.
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The role of ferroptosis in lung cancer.
TL;DR: In this article, the authors summarized the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlighted the induction-related tumor therapies, which may provide new insights for targeted lung cancer therapy.
References
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Journal ArticleDOI
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell,José Pedro Friedmann Angeli,Hülya Bayır,Ashley I. Bush,Marcus Conrad,Scott J. Dixon,Simone Fulda,Susan Gascon,Stavroula K. Hatzios,Valerian E. Kagan,Kay Noel,Xuejun Jiang,Andreas Linkermann,Maureen E. Murphy,Michael Overholtzer,Atsushi Oyagi,Gabriela Carolina Pagnussat,Jason Park,Qitao Ran,Craig S. Rosenfeld,Konstantin Salnikow,Daolin Tang,Daolin Tang,Frank M. Torti,Suzy V. Torti,Shinya Toyokuni,K. A. Woerpel,Donna D. Zhang +27 more
TL;DR: The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended.
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New driver mutations in non-small-cell lung cancer
William Pao,Nicolas Girard +1 more
TL;DR: Subsets defined by so-called driver mutations in ALK, HER2, BRAF, PIK3CA, AKT1, MAP2K1, and MET are reviewed.
Journal ArticleDOI
Global Epidemiology of Lung Cancer
TL;DR: The evidence on lung cancer epidemiology, including data of international scope with comparisons of economically, socially, and biologically different patient groups is reviewed, including a discussion on the epidemiologic characteristics of special groups including women and nonsmokers.
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Role of GPX4 in ferroptosis and its pharmacological implication
TL;DR: An overview of what is known about ferroptosis today and its future translational impact is provided to provide an overview of the rapidly growing interest in this form of cell death.
Journal ArticleDOI
mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
Yilei Zhang,Robert V. Swanda,Litong Nie,Xiaoguang Liu,Chao Wang,Hyemin Lee,Guang Lei,Chao Mao,Pranavi Koppula,Pranavi Koppula,Weijie Cheng,Jie Zhang,Zhenna Xiao,Li Zhuang,Bingliang Fang,Junjie Chen,Shu-Bing Qian,Boyi Gan,Boyi Gan +18 more
TL;DR: In this article, the authors perform integrated proteomic and functional analyses to reveal that SLC7A11-mediated cystine uptake promotes not only GSH synthesis, but also GPX4 protein synthesis.