Inhibition of Leishmania major PTR1 Gene Expression by Antisense in Escherichia coli.
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"Inhibition of Leishmania major PTR1..." refers background in this paper
...In addition to reports in the world about Leishmania which is resistant to drugs (19, 20) in Iran 10 to 15 percent of people infected with cutaneous leishmaniasis have been treated with Glucantime; they have no response to treatment that one of the reasons is drug-resistant parasites (21)....
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543 citations
"Inhibition of Leishmania major PTR1..." refers background in this paper
...On the other hand, PTR1 causes synthesis and reduction of pteridine that increases the resistance of parasite against oxidative stress-related drug or reactions of the host (1, 2, 12)....
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252 citations
"Inhibition of Leishmania major PTR1..." refers background or methods in this paper
...As was mentioned DHFR in parasitic DNA synthesis has an important role and inhibit this enzyme is causing the death....
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...Methotrexate, one of anti-metabolite drugs, is an antagonist for folic acid, which competitively will inhibit DHFR, and its result is the death of parasite (24-25)....
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...The enzymatic activity of PTR1 is similar to dihydrofolate reductase (DHFR) (10, 11)....
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...Genesis drugs on metabolism in mediating cell proliferation are important affect; one *Corresponding Author: Tel: +9821 22439956, E-mail address: kazemi@sbmu.ac.ir Available at: http://ijph.tums.ac.ir 66 Available at: http://ijph.tums.ac.ir of the mechanisms of drug is inhibition of DHFR-TS (1)....
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...Since PTR1 activity is similar to DHFR causes the decrease of inhibition effect of drug (10, 11)....
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