Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
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Cites background from "Inhibition of Myc family proteins e..."
...Research in model systems of MYC addiction and withdrawal have validated addiction to this master regulatory transcription factor in solid and hematologic malignancies, both with and without structural changes to the MYC locus itself (Felsher and Bishop, 1999; Jain et al., 2002; Soucek et al., 2008; Soucek et al., 2013)....
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...Research in model systems of MYC addiction and withdrawal have validated addiction to this master regulatory TF in solid and hematologic malignancies, both with and without structural changes to the MYC locus itself (Felsher and Bishop, 1999; Jain et al., 2002; Soucek et al., 2008, 2013)....
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614 citations
Cites background from "Inhibition of Myc family proteins e..."
...Using a dominant negative MYC, designated “omoMYC,” investigators illustrated that conditional suppression of MYC appears to reverse RAS-induced tumorigenesis (Soucek et al. 2008, 2013)....
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