Journal ArticleDOI
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
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TLDR
Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.Abstract:
Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.read more
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Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
Journal ArticleDOI
Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A. Baur,David A. Sinclair +1 more
TL;DR: A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.
Journal ArticleDOI
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
TL;DR: Important insights into the mechanisms of inflammatory responses, pain, and fever have been gleaned from the current understanding of eicosanoid biology.
Journal ArticleDOI
Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis: The CLASS Study: A Randomized Controlled Trial
Fred E. Silverstein,Gerald A. Faich,Jay L. Goldstein,Lee S. Simon,Theodore Pincus,Andrew Whelton,Robert W. Makuch,Glenn M. Eisen,Naurang M. Agrawal,William F. Stenson,Aimee M. Burr,William W. Zhao,Jeffrey D. Kent,James B. Lefkowith,Kenneth M. Verburg,G. Steven Geis +15 more
TL;DR: In this study, celecoxib, at dosages greater than those indicated clinically, was associated with a lower incidence of symptomatic ulcers and ulcer complications combined, as well as other clinically important toxic effects, compared with NSAIDs at standard dosages.
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Ecotoxicology of human pharmaceuticals.
TL;DR: It is shown that only very little is known about long-term effects of pharmaceuticals to aquatic organisms, in particular with respect to biological targets, and targeted ecotoxicological studies are needed focusing on subtle environmental effects.
References
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Journal ArticleDOI
Aspirin selectively inhibits prostaglandin production in human platelets
TL;DR: Platelets in the blood of volunteers who have taken aspirin can no longer produce prostaglandins, and these platelets are removed from the body by the immune system.
Journal ArticleDOI
Indomethacin and aspirin abolish prostaglandin release from the spleen.
TL;DR: The action of these two anti-inflammatory agents provides further support for the suggestion that some of their therapeutic effects depend on the inhibition of the production of prostaglandin.
Journal ArticleDOI
Prostaglandins: Their Disappearance from and Release into the Circulation
S. H. Ferreira,John R. Vane +1 more
TL;DR: The liver and lungs provide an efficient protective mechanism to remove almost all the prostaglandin before it reaches the arterial circulation.
Journal ArticleDOI
Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs
Priscilla J. Piper,John R. Vane +1 more
TL;DR: Among the active substances released during anaphylaxis in guinea-pig lung is a hitherto unidentified substance which has a contracting effect on rabbit aorta.
Journal Article
The prostaglandins: a family of biologically active lipids
TL;DR: The prostaglandins are a family of lipids, originally discovered over 30 years ago in human seminal fluid, which have since been found not only to have a wide variety of striking pharmacological actions, but also to be present in many if not all mammalian tissues.