Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin
Citations
793 citations
166 citations
Cites background from "Inhibition of tumor propellant glut..."
...In addition, GPX4 may potentially be involved in translation of protein, mitochondrial respiratory chain complex I assembly, electron transport oxidative phosphorylation, nonalcoholic fatty liver disease, and metabolic pathways [102]....
[...]
97 citations
89 citations
88 citations
Cites background from "Inhibition of tumor propellant glut..."
...Cisplatin inhibited cancer progression by triggering autophagic cell death [42], apoptosis [43], pyroptosis [17], ferroptosis [44] and necroptosis [45]....
[...]
...studies reported that cisplatin inhibited cancer progression by triggering autophagic cell death [42], apoptosis [43], pyroptosis [17], ferroptosis [44] and...
[...]
References
7,192 citations
"Inhibition of tumor propellant glut..." refers background in this paper
...NCI‐H460, cell proliferation was decreased with GPX4 knockdown and this inhibition could be reversed by ferrostatin‐1 (Fer‐1), the specific inhibitor of ferroptosis (Dixon et al., 2012; Hassannia et al., 2018; Figure 6a)....
[...]
...Further studies identified some of these deaths such as pyroptosis (Zhou et al., 2018), procedural necrosis (Kulaylat et al., 2017), and ferroptosis (Dixon et al., 2012)....
[...]
...Ferroptosis is a type of cell death which is characterized by the elevation of iron and ROS inside cells (Dixon et al., 2012)....
[...]
1,106 citations
"Inhibition of tumor propellant glut..." refers background in this paper
...In our study, we found that knockdown of GPX4 induced ferroptosis in lung cancer cells, this is not new because GPX4 has been confirmed to be the inhibitor of ferroptosis (Chu et al., 2019; Hassannia et al., 2019)....
[...]
...In our study, we found that knockdown of GPX4 induced ferroptosis in lung cancer cells, this is not new because GPX4 has been confirmed to be the inhibitor of ferroptosis (Chu et al., 2019; Hassannia et al., 2019)....
[...]
1,008 citations
"Inhibition of tumor propellant glut..." refers background in this paper
...8 kb and consists of seven exons (Kriska, Korytowski, & Girotti, 2002), and its main function is to eliminate the excess reactive oxygen species (ROS) which causes the injury of DNA (Binder, Papac‐Milicevic, & Witztum, 2016; Meng et al., 2018; Viswanathan et al., 2017)....
[...]
...As epigenetic regulation has been identified as a common type of control in gene expression (Jones, Ohtani, Chakravarthy, & De Carvalho, 2019), we explored whether GPX4 could be epigenetically regulated on the level of DNA methylation and histone modification using the data from the Illumina Infinium Human Methylation 450 platform and ENCODE....
[...]
...Total RNA Kit I (OMEGA, CA: R6834‐01) was used to extract total RNA according to manufacturer’s protocol, the complementary DNA was synthesized using a PrimeScript RT reagent Kit (Takara Bio, Otsu, Japan), messenger RNA expression was examined by real‐time polymerase chain reaction (RT‐PCR) using FastStart Universal SYBR Green Master Mix (Roche, Mannheim, Germany) with primers and an ABI StepOne Plus Real‐time PCR Detection System (Applied Biosystems, Foster City, CA)....
[...]
...The structure of GPX4 spans only 2.8 kb and consists of seven exons (Kriska, Korytowski, & Girotti, 2002), and its main function is to eliminate the excess reactive oxygen species (ROS) which causes the injury of DNA (Binder, Papac‐Milicevic, & Witztum, 2016; Meng et al., 2018; Viswanathan et al., 2017)....
[...]
...Furthermore, we investigated the probable epigenetic regulation of GPX4 and we found that higher level of GPX4 was epigenetically regulated via low DNA methylation and enhanced level of histone methylation and acetylation....
[...]
862 citations
"Inhibition of tumor propellant glut..." refers background in this paper
..., 2018), however, the inhibition of GPX4 induces suppression of tumors although the level of ROS elevated, especially in drug‐resistant tumors (Gaschler et al., 2018; Hangauer et al., 2017)....
[...]
...This may explain why higher expression of GPX4 indicates bad prognosis in patients who had received anticancer therapies (Hangauer et al., 2017)....
[...]
...…GPX4 is the “cleaner” of ROS, it seems that inhibition of GPX4 leads to the growth of tumors (Teng et al., 2018), however, the inhibition of GPX4 induces suppression of tumors although the level of ROS elevated, especially in drug‐resistant tumors (Gaschler et al., 2018; Hangauer et al., 2017)....
[...]
516 citations
"Inhibition of tumor propellant glut..." refers background in this paper
...Second, as the core member of ferroptosis, ROS participates in various pathways (Hervera et al., 2018; Villegas et al., 2018), whether the intervening of GPX4 would (a) (c) (d) (f)(e) (g) (b) F IGURE 8 GPX4 inhibition enhances anticnacer effect of cis via autophagy in vitro and vivo....
[...]