Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury
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"Inhibitor of apoptosis-stimulating ..." refers background in this paper
...lation and nuclear translocation of nuclear factor (erythroidderived 2)-like 2 (Nrf2) [15], a transcription factor that...
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...Ferroptosis has also been reported to promote tumor cell death, and small molecules that induce ferroptosis, such as erastin, have potential in cancer treatments [15]....
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...p53, a tumor suppressor, is stimulated by apoptosisstimulating protein of p53 and consequently induces apoptosis and ferroptosis in response to DNA damage [15]....
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...Interestingly, inhibitor of apoptosis-stimulating protein of p53 (iASPP) inhibits p53-induced apoptosis and facilitates tumor growth, and the overexpression of iASPP induces chemoresistance in human cancer cells [15]....
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