Initial results from a forward-viewing ring-annular ultrasound array for intravascular imaging
05 Oct 2003-Vol. 1, pp 212-215
TL;DR: In this paper, a forward viewing ring-annular array for intravascular ultrasound imaging has been proposed, which is appropriate for over-the-wire delivery but limits the forward-looking aperture to a ring-ANNular array.
Abstract: In this paper, we present some initial results from our proposed forward viewing ring-annular array for intravascular ultrasound imaging. We have investigated array design and image synthesis allowing simultaneous sideward imaging at 20 MHz and forward imaging at 10 MHz from the same array. This design is appropriate for over-the-wire delivery but limits the forward-looking aperture to a ring-annular array. In particular, a 1200 /spl mu/m diameter ring-annular array with 64 elements has been constructed. The measured forward- viewing radiation pattern of an individual element indicates an acceptance angle range of over 90/spl deg/. Currently, there are significant sensitivity and center frequency variations among the elements. Nevertheless, images of point targets are obtained as a proof-of-concept. Future improvements of the array will be discussed.
Citations
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TL;DR: It is demonstrated that annular-ring CMUT arrays fabricated with CMOS-compatible processes are capable of forward-looking IVUS imaging, and the developed modeling tools can be used to design improved IVUS Imaging arrays.
Abstract: In this study, a 64-element, 1.15-mm diameter annular-ring capacitive micromachined ultrasonic transducer (CMUT) array was characterized and used for forward-looking intravascular ultrasound (IVUS) imaging tests. The array was manufactured using low-temperature processes suitable for CMOS electronics integration on a single chip. The measured radiation pattern of a 43 /spl times/ 140-/spl mu/m array element depicts a 40/spl deg/ view angle for forward-looking imaging around a 15-MHz center frequency in agreement with theoretical models. Pulse-echo measurements show a -10-dB fractional bandwidth of 104% around 17 MHz for wire targets 2.5 mm away from the array in vegetable oil. For imaging and SNR measurements, RF A-scan data sets from various targets were collected using an interconnect scheme forming a 32-element array configuration. An experimental point spread function was obtained and compared with simulated and theoretical array responses, showing good agreement. Therefore, this study demonstrates that annular-ring CMUT arrays fabricated with CMOS-compatible processes are capable of forward-looking IVUS imaging, and the developed modeling tools can be used to design improved IVUS imaging arrays.
152 citations
TL;DR: This work presents compelling, full-synthetic, phased-array volumetric images from a forward-viewing capacitive micromachined ultrasonic transducer (CMUT) ring array wire bonded to a custom integrated circuit front end.
Abstract: Forward-viewing ring arrays can enable new applications in intravascular and intracardiac ultrasound. This work presents compelling, full-synthetic, phased-array volumetric images from a forward-viewing capacitive micromachined ultrasonic transducer (CMUT) ring array wire bonded to a custom integrated circuit front end. The CMUT ring array has a diameter of 2 mm and 64 elements each 100 /spl mu/m /spl times/ 100 /spl mu/m in size. In conventional mode, echo signals received from a plane reflector at 5 mm had 70% fractional bandwidth around a center frequency of 8.3 MHz. In collapse mode, 69% fractional bandwidth is measured around 19 MHz. Measured signal-to-noise ratio (SNR) of the echo averaged 16 times was 29 dB for conventional operation and 35 dB for collapse mode. B-scans were generated of a target consisting of steel wires 0.3 mm in diameter to determine resolution performance. The 6 dB axial and lateral resolutions for the B-scan of the wire target are 189 /spl mu/m and 0.112 radians for 8 MHz, and 78 /spl mu/m and 0.051 radians for 19 MHz. A reduced firing set suitable for real-time, intravascular applications was generated and shown to produce acceptable images. Rendered three-dimensional (3-D) images of a Palmaz-Schatz stent also are shown, demonstrating that the imaging quality is sufficient for practical applications.
142 citations
TL;DR: The results show that SPA with Hadamard coding and aperture weighting is a good option for ring-array imaging, which achieves better image resolution and comparable signal-tonoise ratio at a much faster image acquisition rate.
Abstract: A ring array provides a very suitable geometry for forward-looking volumetric intracardiac and intravascular ultrasound imaging. We fabricated an annular 64-element capacitive micromachined ultrasonic transducer (CMUT) array featuring a 10-MHz operating frequency and a 1.27-mm outer radius. A custom software suite was developed to run on a PCbased imaging system for real-time imaging using this device. This paper presents simulated and experimental imaging results for the described CMUT ring array. Three different imaging methods-flash, classic phased array (CPA), and synthetic phased array (SPA)-were used in the study. For SPA imaging, two techniques to improve the image quality-Hadamard coding and aperture weighting-were also applied. The results show that SPA with Hadamard coding and aperture weighting is a good option for ring-array imaging. Compared with CPA, it achieves better image resolution and comparable signal-tonoise ratio at a much faster image acquisition rate. Using this method, a fast frame rate of up to 463 volumes per second is achievable if limited only by the ultrasound time of flight; with the described system we reconstructed three cross-sectional images in real-time at 10 frames per second, which was limited by the computation time in synthetic beamforming.
42 citations
TL;DR: In this article, two 2D array transducers integrated into a Cook Medical, Inc. inferior vena cava (IVC) filter deployment device have been described, which can be used to efficiently manufacture these types of devices in greater than prototype numbers.
39 citations
TL;DR: An 80-element lead zirconium titanate matrix ultrasound transducer for FL-IVUS imaging with a front-end application-specific integrated circuit (ASIC) requiring only four cables is presented.
Abstract: Intravascular ultrasound (IVUS) is an imaging modality used to visualize atherosclerosis from within the inner lumen of human arteries. Complex lesions like chronic total occlusions require forward-looking IVUS (FL-IVUS), instead of the conventional side-looking geometry. Volumetric imaging can be achieved with 2-D array transducers, which present major challenges in reducing cable count and device integration. In this work, we present an 80-element lead zirconium titanate matrix ultrasound transducer for FL-IVUS imaging with a front-end application-specific integrated circuit (ASIC) requiring only four cables. After investigating optimal transducer designs, we fabricated the matrix transducer consisting of 16 transmit (TX) and 64 receive (RX) elements arranged on top of an ASIC having an outer diameter of 1.5 mm and a central hole of 0.5 mm for a guidewire. We modeled the transducer using finite-element analysis and compared the simulation results to the values obtained through acoustic measurements. The TX elements showed uniform behavior with a center frequency of 14 MHz, a −3-dB bandwidth of 44%, and a transmit sensitivity of 0.4 kPa/V at 6 mm. The RX elements showed center frequency and bandwidth similar to the TX elements, with an estimated receive sensitivity of $3.7~\mu \text{V}$ /Pa. We successfully acquired a 3-D FL image of three spherical reflectors in water using delay-and-sum beamforming and the coherence factor method. Full synthetic-aperture acquisition can be achieved with frame rates on the order of 100 Hz. The acoustic characterization and the initial imaging results show the potential of the proposed transducer to achieve 3-D FL-IVUS imaging.
28 citations
References
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TL;DR: In this article, a 64-element, high efficiency, ceramic piezoelectric array transducer operating at 20 MHz has been constructed for ultrasonic intraluminal imaging.
Abstract: A 64-element, high efficiency, ceramic piezoelectric array transducer operating at 20 MHz has been constructed for ultrasonic intraluminal imaging. The array is mounted on the surface of a 1.2 mm diameter catheter appropriate for coronary artery applications. Integrated into the catheter tip is a custom analog chip set permitting complete data capture from the array. That is, on each firing any combination of array elements can be selected independently as transmitter or receiver. Using data acquired in this way, a complete phased array aperture (i.e., independent transmit and receive apertures) can be synthesized. Reconstruction hardware based on a custom application specific integrated circuit (ASIC) has been designed and built to produce real-time images. Beam forming coefficients are derived using an optimal filtering approach accounting for the circular geometry of the array. Simulated and measured beam patterns for this system are compared. In addition, images of coronary anatomy acquired with the real-time system are displayed demonstrating the marked image quality improvement compared to previous synthetic aperture intraluminal systems.
109 citations
TL;DR: A practical array geometry and signal processing architecture for a forward-viewing IVUS system that can achieve side-lobes under -40 dB for on-axis situations and under -30 dB for steering to the edge of a 60/spl deg/ cone.
Abstract: Intravascular ultrasound (IVUS) imaging systems using circumferential arrays mounted on cardiac catheter tips fire beams orthogonal to the principal axis of the catheter. The system produces high resolution cross-sectional images but must be guided by conventional angioscopy. A real-time forward-viewing array, integrated into the same catheter, could greatly reduce radiation exposure by decreasing angiographic guidance. Unfortunately, the mounting requirement of a catheter guide wire prohibits a full-disk imaging aperture. Given only an annulus of array elements, prior theoretical investigations have only considered a circular ring of point transceivers and focusing strategies using all elements in the highly dense array, both impractical assumptions. In this paper, we consider a practical array geometry and signal processing architecture for a forward-viewing IVUS system. Our specific design uses a total of 210 transceiver firings with synthetic reconstruction for a given 3-D image frame. Simulation results demonstrate this design can achieve side-lobes under -40 dB for on-axis situations and under -30 dB for steering to the edge of a 60/spl deg/ cone.
85 citations
TL;DR: Preliminary data suggest that a forward- viewing IVUS catheter is feasible, accurate, and useful for evaluation of arterial geometry distal to the catheter tip.
Abstract: BACKGROUND Intravascular ultrasound (IVUS) of arteries is limited by the inability of current instruments to visualize beyond the catheter tip. We have developed a prototype 4-mm-diameter forward-viewing IVUS catheter (Cardiovascular Imaging Systems, Sunnyvale, Calif) that has the ability to provide B-mode cross-sectional ultrasound data for a distance of up to 2 cm distal to the catheter tip. METHODS AND RESULTS To study the utility of this device, a 20-MHz forward-viewing IVUS catheter was used to examine 13 arterial segments (5 human femoral arteries, 1 human carotid artery, 7 canine arteries) in vitro and 1 phantom. After imaging, all data were compared with histology (Histo). In all cases, the IVUS catheter provided forward-viewing images corresponding to the arterial geometry and demonstrated vascular landmarks and atherosclerotic lesions. There was a good correlation between Histo-determined luminal diameters (LD) and IVUS-determined diameters for a distance of 14 mm ahead of the catheter tip: IVUS LD = 1.0 Histo LD + 1.3 (r = .87). CONCLUSIONS These preliminary data suggest that a forward-viewing IVUS catheter is feasible, accurate, and useful for evaluation of arterial geometry distal to the catheter tip.
80 citations
TL;DR: Preliminary data demonstrate the feasibility of 3DR of forward-viewing IVUS data and allows rapid, detailed analysis of diseased arterial segments previously unavailable with standard IVUS and may permit better targeting of interventional techniques.
Abstract: BACKGROUND: Current intravascular ultrasound (IVUS) catheters provide transverse imaging at the level of the ultrasound transducer. This limits imaging to large-diameter segments without critical atherosclerotic narrowings. We have developed a prototype 20-MHz forward-viewing IVUS catheter that provides two-dimensional sector imaging distal to the catheter tip. A present limitation of this technique is that the catheter must be manually rotated to obtain multiple longitudinal views required to integrate the segment into a three-dimensional matrix. To overcome this, we have developed an algorithm that reconstructs these multiple two-dimensional forward-viewing IVUS images into a three-dimensional matrix for more complete depiction of the segment distal to the ultrasound catheter. This algorithm allows display and multidimensional slicing of the three-dimensional reconstruction. METHODS AND RESULTS. To test our algorithms, five arterial segments (three canine aortas, two human femoral arteries) were evaluated in vitro. In each segment, 36 forward-viewing longitudinal slices were collected, digitized, processed, and reoriented to produce a three-dimensional reconstruction (3DR) matrix. The matrix data were sliced into parallel transverse sections and compared with morphometric interpretation of histological sections (Histo). As a result, image data could be reconstructed for a distance of 2.0 cm ahead of the catheter. 3DR easily demonstrated wall and luminal morphology and provided transverse IVUS images comparable to the histological specimens. A good correlation was noted between Histo- and 3DR-determined luminal diameters (LD) and luminal areas: 3DR LD = 1.4 Histo LD-0.4, r = .86; 3DR LD = 0.7 +/- 0.20 cm (mean +/- SD); and Histo LD = 0.7 +/- 0.13 cm. CONCLUSIONS: These preliminary data demonstrate the feasibility of 3DR of forward-viewing IVUS data. This method allows rapid, detailed analysis of diseased arterial segments previously unavailable with standard IVUS and may permit better targeting of interventional techniques.
70 citations
TL;DR: A formulation of the scheme, according to which CEXSI can be extended to improve SNR in sparse array imaging in general, and its potential to achieve excellent decoding with very low (<80 dB) side-lobes is demonstrated.
Abstract: In this paper, a scheme called coded excitation with spectrum inversion (CEXSI) is presented. An established optimal binary code whose spectrum has no nulls and possesses the least variation is encoded as a burst for transmission. Using this optimal code, the decoding filter can be derived directly from its inverse spectrum. Various transmission techniques can be used to improve energy coupling within the system pass-band. We demonstrate its potential to achieve excellent decoding with very low (<80 dB) side-lobes. For a 2.6 /spl mu/s code, an array element with a center frequency of 10 MHz and fractional bandwidth of 38%, range side-lobes of about 40 dB have been achieved experimentally with little compromise in range resolution. The signal-to-noise ratio (SNR) improvement also has been characterized at about 14 dB. Along with simulations and experimental data, we present a formulation of the scheme, according to which CEXSI can be extended to improve SNR in sparse array imaging in general.
49 citations