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Initial sequencing and analysis of the human genome.

Eric S. Lander, +248 more
- 15 Feb 2001 - 
- Vol. 409, Iss: 6822, pp 860-921
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TLDR
The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Abstract: 
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.

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Journal ArticleDOI

Widespread horizontal transfer of mitochondrial genes in flowering plants

Ulfar Bergthorsson, +5 more
- 10 Jul 2003 - 
TL;DR: It is shown that standard mitochondrial genes, encoding ribosomal and respiratory proteins, are subject to evolutionarily frequent horizontal transfer between distantly related flowering plants, implying the existence of mechanisms for the delivery of DNA between unrelated plants and indicating that horizontal transfer is also a force in plant nuclear genomes.
Journal ArticleDOI

Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins.

Jun Zhu, +2 more
- 01 Dec 2001 - 
TL;DR: The differential antagonism between a negative and two positive regulators exemplifies how inclusion of an alternative exon can be modulated.
Journal ArticleDOI

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

Zhijian Li, +31 more
- 01 Apr 2011 - 
TL;DR: This mutant collection should facilitate a wide range of systematic studies aimed at understanding the functions of essential genes, including roles for cohesin and condensin genes in spindle disassembly.
Journal ArticleDOI

Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction.

Shawn S.-C. Li
- 15 Sep 2005 - 
TL;DR: Structural and biochemical analysis of many interaction domains in recent years has started to shed light on the molecular basis underlying specific compared with diverse binding events that are mediated by interaction domains and the role affinity plays in affecting domain specificity and regulating cellular signal transduction.
Journal ArticleDOI

Gene Co-Option in Physiological and Morphological Evolution

John R. True, +1 more
- 02 Apr 2002 - 
TL;DR: A framework for understanding the origin of co-optive evolution and the mechanisms by which natural selection promotes evolutionary novelty by inventing new uses for the genetic toolkit is provided.
References
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Journal ArticleDOI

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

Stephen F. Altschul, +6 more
- 01 Sep 1997 - 
TL;DR: A new criterion for triggering the extension of word hits, combined with a new heuristic for generating gapped alignments, yields a gapped BLAST program that runs at approximately three times the speed of the original.
Journal ArticleDOI

The Pfam protein families database

Marco Punta, +15 more
- 01 Jan 2000 - 
TL;DR: The definition and use of family-specific, manually curated gathering thresholds are explained and some of the features of domains of unknown function (also known as DUFs) are discussed, which constitute a rapidly growing class of families within Pfam.
Journal ArticleDOI

The sequence of the human genome.

J. Craig Venter, +272 more
- 16 Feb 2001 - 
TL;DR: Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems are indicated.
Journal ArticleDOI

Identification of common molecular subsequences.

Temple F. Smith, +1 more
- 25 Mar 1981 - 
TL;DR: This letter extends the heuristic homology algorithm of Needleman & Wunsch (1970) to find a pair of segments, one from each of two long sequences, such that there is no other Pair of segments with greater similarity (homology).
Journal ArticleDOI

Sequence and organization of the human mitochondrial genome

Stephen Anderson, +17 more
TL;DR: The complete sequence of the 16,569-base pair human mitochondrial genome is presented and shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
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