Initial sequencing and analysis of the human genome.

doi:10.1038/35057062

Open AccessJournal ArticleDOI

Initial sequencing and analysis of the human genome.

Eric S. Lander, +248 more

- 15 Feb 2001 -

Nature

- Vol. 409, Iss: 6822, pp 860-921

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TLDR

The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.

Abstract:

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.

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Finishing the euchromatic sequence of the human genome

Chris P. Ponting, +1 more

- 21 Oct 2004 -

Nature

TL;DR: The current human genome sequence (Build 35) as discussed by the authors contains 2.85 billion nucleotides interrupted by only 341 gaps and is accurate to an error rate of approximately 1 event per 100,000 bases.

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A Draft Sequence of the Neandertal Genome

Richard E. Green, +58 more

- 07 May 2010 -

Science

TL;DR: The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.

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A gene atlas of the mouse and human protein-encoding transcriptomes

Andrew I. Su, +14 more

- 20 Apr 2004 -

Proceedings of the National Academy of S...

TL;DR: In this paper, high-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a genome scale, and the authors have designed custom arrays that interrogate the expression of the vast majority of proteinencoding human and mouse genes and have used them to profile a panel of 79 human and 61 mouse tissues.

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An efficient algorithm for large-scale detection of protein families

Anton J. Enright, +2 more

- 01 Apr 2002 -

Nucleic Acids Research

TL;DR: This work presents a novel approach called TRIBE-MCL for rapid and accurate clustering of protein sequences into families based on precomputed sequence similarity information that has been rigorously tested and validated on a number of very large databases.

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References

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Nucleic Acids Research

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J. Craig Venter, +272 more

- 16 Feb 2001 -

Science

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Temple F. Smith, +1 more

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Journal of Molecular Biology

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Sequence and organization of the human mitochondrial genome

Stephen Anderson, +17 more

TL;DR: The complete sequence of the 16,569-base pair human mitochondrial genome is presented and shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.

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