Journal ArticleDOI
Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force.
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TLDR
The ability to predict insertion and fracture forces is provided, which facilitates rational design of microneedles with robust mechanical properties.About:
This article is published in Journal of Biomechanics.The article was published on 2004-08-01. It has received 659 citations till now.read more
Citations
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Journal ArticleDOI
Microneedles for transdermal drug delivery.
TL;DR: Microneedles represent a promising technology to deliver therapeutic compounds into the skin for a range of possible applications and the ratio of microneedle fracture force to skin insertion force was found to be optimal for needles with small tip radius and large wall thickness.
Journal ArticleDOI
Microneedles for drug and vaccine delivery.
TL;DR: Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.
Journal ArticleDOI
Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery
TL;DR: Results indicate that biodegradable polymer microneedles can be fabricated with an appropriate geometry and sufficient strength to insert into skin, and thereby dramatically increase transdermal transport of molecules.
Journal ArticleDOI
Dissolving microneedles for transdermal drug delivery.
TL;DR: It is concluded that dissolving microneedles can be designed to gently encapsulate molecules, insert into skin, and enable bolus or sustained release delivery and leave behind no biohazardous sharp medical waste.
Journal ArticleDOI
Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
TL;DR: In this paper, a review of microneedle arrays can increase the number of compounds amenable to transdermal delivery by penetrating the skin's protective barrier, the stratum corneum, and creating a pathway for drug permeation to the dermal tissue below.
References
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Book
Theory and Practice of Histological Techniques
John D. Bancroft,Marilyn Gamble +1 more
TL;DR: Light Microscopy, Enzyme Histochemistry, and Immunocytochemical Techniques: Diagnostic Cytopathology, Specimen Collection and Preparation.
Physicians Desk Reference
TL;DR: In this paper, the authors present a list of manufacturers, product categories, and diagnostic product information, including name, product category, and identification of product categories and attributes, with a focus on medical applications.
Journal Article
Drug delivery and targeting
TL;DR: When a pharmaceutical agent is encapsulated within, or attached to, a polymer or lipid, drug safety and efficacy can be greatly improved and new therapies are possible.
Book
Formulas for Stress and Strain
TL;DR: In this article, the authors propose formulas for stress and strain in the form of formulas for strain and stress, which are derived from the formula for stress-and-stress and strain.
Journal ArticleDOI
Microfabricated microneedles: a novel approach to transdermal drug delivery.
TL;DR: These microneedle arrays could be easily inserted into skin without breaking and were shown to increase permeability of human skin in vitro to a model drug, calcein, by up to 4 orders of magnitude.