Insight of magnesium alloys and composites for orthopedic implant applications – a review
TL;DR: In this article, a review comprehensively describes the strategies for improving the mechanical and degradation performance of Mg alloys through properly tailoring the composition of alloying elements, reinforcements and processing techniques.
About: This article is published in Journal of Magnesium and Alloys.The article was published on 2017-09-01 and is currently open access. It has received 293 citations till now.
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TL;DR: A comprehensive review of different grades of biodegradable magnesium matrix composites including their mechanical properties and corrosion resistance is presented in this article, where the matrix materials are biomedical magnesium alloys base like Mg-Ca, Mg−Zn, and Mg•REE alloy and reinforcements are based on hydroxyapatite (HAP), calcium polyphosphate (CPP), and β-tricalcium phosphate (β-TCP) particles.
220 citations
TL;DR: This paper provides a review of state-of-the-art of magnesium alloy implants for orthopedic and tissue engineering applications and describes recent progress in the design of novel structure design Mg alloys and potential approaches to improve their biodegradation performance.
Abstract: The study of innovative biodegradable implant materials is one of the most interesting research topics at the forefront in the area of biomaterials. Biodegradable implant materials in the human body can be gradually dissolved, absorbed, consumed or excreted, so there is no need for the secondary surgery to remove implants after the surgery regions have healed. However, most of the biodegradable materials, usually polymers, do not have good mechanical properties to be reliable for bearing the load of the body. Magnesium and its alloys due to the excellent biodegradability and biocompatibility as well as the suitable mechanical compatibility with human bone are very promising candidates for the development of temporary, degradable implants in load-bearing applications. However, Mg alloys are corrosion susceptible in a biological environment. Besides, the high corrosion rate and the low bioactivity of magnesium implants are the challenging problems, which need to be resolved before employing them in clinical applications. This paper provides a review of state-of-the-art of magnesium alloy implants for orthopedic and tissue engineering applications and describes recent progress in the design of novel structure design Mg alloys and potential approaches to improve their biodegradation performance.
172 citations
TL;DR: Recent research and development on Zn-based BMs are reviewed in conjunction with discussion of their advantages and limitations in relation to existing BMs, and the underlying roles of alloy composition, microstructure, and processing technique on the mechanical and corrosion properties are discussed.
170 citations
Cites background from "Insight of magnesium alloys and com..."
...Table 8 Properties and biomedical applications of various ceramic reinforcement materials [40,295,296]....
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TL;DR: In this article, a review of the mechanical properties and corrosion behavior of modern Mg-based biocomposites and alloys for biomedical applications is presented. And the corrosion resistance is related to the stability of deposits and their chemical stability in in vitro and in vitro environments.
160 citations
TL;DR: In this article, the impact and importance of biodegradable Mg alloys, reviewing the beginning of their development, the significant characteristics that make them so desirable for such applications (orthopedic implants) but also the characteristics that must be modulated (corrosion rate and mechanical properties) to arrive at the ideal product for the targeted application.
137 citations
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TL;DR: A review of the properties, biological performance, challenges and future directions of magnesium-based biomaterials can be found in this paper, where the authors explore the properties and challenges of magnesium biomaterial.
3,757 citations
TL;DR: Magnesium and its alloys have been investigated recently by many authors as a suitable biodegradable biomaterial as mentioned in this paper, and the latest achievements and comment on the selection and use, test methods and the approaches to develop and produce magnesium alloys that are intended to perform clinically with an appropriate host response.
Abstract: Biodegradable metals are breaking the current paradigm in biomaterial science to develop only corrosion resistant metals. In particular, metals which consist of trace elements existing in the human body are promising candidates for temporary implant materials. These implants would be temporarily needed to provide mechanical support during the healing process of the injured or pathological tissue. Magnesium and its alloys have been investigated recently by many authors as a suitable biodegradable biomaterial. In this investigative review we would like to summarize the latest achievements and comment on the selection and use, test methods and the approaches to develop and produce magnesium alloys that are intended to perform clinically with an appropriate host response.
1,569 citations
TL;DR: The results of tensile tests and in vitro corrosion tests indicated that Mg-1Ca alloy had the acceptable biocompatibility as a new kind of biodegradable implant material and a solid alloy/liquid solution interface model was proposed to interpret the biocorrosion process and the associated hydroxyapatite mineralization.
1,385 citations
TL;DR: Results of this study suggest, that the conclusions drawn from current ASTM standard in vitro corrosion tests cannot be used to predict in vivo corrosion rates of magnesium alloys.
1,237 citations
TL;DR: It was found that hemolysis and the amount of adhered platelets decreased after alloying for all Mg-1X alloys as compared to the pure magnesium control.
1,174 citations