Instrumental Activities of Daily Living as a Potential Marker of Frailty A Study of 7364 Community-Dwelling Elderly Women (the EPIDOS Study)
Fati Nourhashemi,Sandrine Andrieu,Sophie Gillette-Guyonnet,Bruno Vellas,Jean Louis Albarede,Hélène Grandjean +5 more
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TLDR
The results confirmed that women with disability on at least one IADL item are frailer because they had more associated disorders, poorer cognitive function and more frequent falls.Abstract:
Background. A number of clinical conditions have been shown to be associated with frailty in elderly people. We hypothesized that incapacities on the Instrumental Activities of Daily Living (IADLs) scale could make it possible to identify this population. We investigated the associations between IADL incapacities and the various known correlates of frailty in a cohort of community-dwelling elderly women. Methods. Cross-sectional analysis was carried out on the data from 7364 women aged over 75 years (EPIDOS Study). The IADL was the dependent variable. Sociodemographic, medical, and psychological performance measures were obtained during an assessment visit. Falls in the previous 6 months and fear of falling were also ascertained. Body composition was measured by dual-energy x-ray absorptiometry. The factors associated with disability in at least one IADL were included in a logistic regression model. Results. Thirty-two percent of the population studied had disability in at least one IADL item. This group was significantly older (81.7 � 4.1 yr vs 79.8 � 3.4 yr), had more frequent histories of heart disease, stroke, depression or diabetes, and was socially less active ( p � .001). These associations persisted after multivariate analysis. Cognitive impairment as assessed by the Pfeiffer test (Pfeiffer score � 8) was closely associated with disabilities on the IADL (OR 3.101, 95% confidence interval [CI] 2.19‐4.38). Falls and fear of falling were also more frequent in the group of women with an abnormal IADL ( p � .001) but only fear of falling remained significantly associated with incapacities on at least one IADL item after logistic regression (OR 1.47, 95% CI 1.28‐1.69). Women with disability on at least one IADL item also had lower bone mineral density, this was independent of the other factors. Conclusion. Our results confirmed that women with disability on at least one IADL item are frailer because they had more associated disorders, poorer cognitive function and more frequent falls. Disabilities on this scale could be a good tool for identifying individuals at risk of frailty among elderly persons living at home and in apparent good health. This finding requires confirmation by longitudinal studies.read more
Citations
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Associations of Sedentary Time and Breaks in Sedentary Time With Disability in Instrumental Activities of Daily Living in Community-Dwelling Older Adults
TL;DR: Findings suggest not only total ST but also the manner in which it is accumulated may contribute to the maintenance of functional independence in older adults.
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Trajectories of cognitive decline and functional status in the frail older adults.
Rossitza Nikolova,Rossitza Nikolova,Louise Demers,Louise Demers,François Béland,François Béland +5 more
TL;DR: Substantial functional deterioration over time was observed for the participants with catastrophic cognitive decline, and IADL were found to deteriorate more than ADL.
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Validation of nutritional screening tools against anthropometric and functional assessments among elderly people in selangor.
S. Suzana,Siti Saifa H +1 more
TL;DR: MNA-SF is considered the most appropriate tool to be used in health clinics for identification of elderly individuals who are at high risk of malnutrition.
Journal ArticleDOI
Frailty Status in Older Adults Is Related to Alterations in Indoleamine 2,3-Dioxygenase 1 and Guanosine Triphosphate Cyclohydrolase I Enzymatic Pathways.
Diego Marcos-Pérez,María Sánchez-Flores,Ana Maseda,Laura Lorenzo-López,José Carlos Millán-Calenti,Barbara Strasser,Johanna M. Gostner,Dietmar Fuchs,Eduardo Pásaro,Vanessa Valdiglesias,Blanca Laffon +10 more
TL;DR: Results obtained in the present study are consistent with the idea that frailty status in the elderly is associated with an additional degree of immune stimulation, manifested in a more intense disturbance of indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I pathways than in nonfrail or prefrail older adults.
Journal ArticleDOI
Malnutrition according to ESPEN definition predicts long-term mortality in general older population: Findings from the EPIDOS study-Toulouse cohort.
Dolores Sánchez-Rodríguez,Ester Marco,Anne-Marie Schott,Yves Rolland,Hubert Blain,Olga Vázquez-Ibar,Ferran Escalada,Xavier Duran,Josep M. Muniesa,Cédric Annweiler +9 more
TL;DR: Although malnutrition prevalence according to the ESPEN definition was relatively low in this sample of otherwise healthy community-dwelling older French women, malnutrition was associated with 4.4-fold higher mortality risk at 12-year follow-up.
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