Insulin action and resistance in obesity and type 2 diabetes
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Cites background from "Insulin action and resistance in ob..."
...This effect increases blood glucose levels, which in turn stimulates the β-cell insulin secretion [16]....
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626 citations
Cites background from "Insulin action and resistance in ob..."
...IR refers to a decrease in the metabolic response of insulin-responsive cells to insulin or, at a systemic level, an impaired/lower response to circulating insulin by blood glucose levels [153]....
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...systemic level, an impaired/lower response to circulating insulin by blood glucose levels [153]....
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...Among the signaling elements affected by adipose-IR, we found that defective AKT activation impairs GLUT4 translocation to the membrane and promotes the activation of lipolytic enzymes that aggravate hyperglycemia [153]....
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...Mutations that reduce the expression of insulin receptor or GLUT4, as well as any defect in either upstream or downstream signaling pathway would reduce glucose intake into the muscle resulting in a hyperglycaemic state [153,160]....
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