Integrated Core Proteomics, Subtractive Proteomics, and Immunoinformatics Investigation to Unveil a Potential Multi-Epitope Vaccine against Schistosomiasis.
Abdur Rehman,Sajjad Ahmad,Farah Shahid,Aqel Albutti,Ameen S. S. Alwashmi,Mohammad Aljasir,Naif Alhumeed,Muhammad Qasim,Usman Ali Ashfaq,Muhammad Tahir ul Qamar +9 more
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TLDR
In this paper, the authors combined core proteomics with a subtractive proteomics pipeline to identify suitable antigenic proteins for the construction of a multi-epitope vaccine (MEV) against human-infecting Schistosoma species.About:
This article is published in Vaccine.The article was published on 2021-06-16 and is currently open access. It has received 26 citations till now. The article focuses on the topics: Epitope & Schistosoma mansoni.read more
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Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents.
Sheema Hashem,Tayyibah Ali,Sabah Akhtar,Sabah Nisar,Geetanjali Sageena,Shahida M. Ali,Sharefa Al-Mannai,Lubna Therachiyil,Rashid Mir,Imadeldin Elfaki,Mohammad Muzaffar Mir,Farrukh Jamal,Tariq Masoodi,Shahab Uddin,Mayank Singh,Mohammad Haris,Muzafar A. Macha,Ajaz A. Bhat +17 more
TL;DR: In this article , a review explores the significance of natural products in inhibiting the various signaling pathways that serve as drivers of carcinogenesis and thus pave the way for developing and discovering anticancer drugs.
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Pan-vaccinomics approach towards a universal vaccine candidate against WHO priority pathogens to address growing global antibiotic resistance.
Saba Ismail,Farah Shahid,Abbas Khan,Sadia Bhatti,Sajjad Ahmad,Anam Naz,Ahmad Almatroudi,Muhammad Tahir ul Qamar +7 more
TL;DR: In this article, the authors used pan-genomics, subtractive proteomics, reverse vaccinology, immunoinformatics, molecular docking and dynamics simulation studies to identify a universal potential vaccine candidate against the 18 multi-drug resistance (MDRs) bacterial pathogenic species from a WHO priority list.
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Designing a Recombinant Vaccine against Providencia rettgeri Using Immunoinformatics Approach
Saba Gul,Sajjad Ahmad,Asad Ullah,Saba Ismail,Muhammad Khurram,Muhammad Tahir ul Qamar,Abdulrahim R. Hakami,Ali G. Alkhathami,Faris Alrumaihi,Khaled S Allemailem +9 more
TL;DR: Findings of the current study are promising and may help experimental vaccinologists to formulate a novel multi-epitope vaccine against P. rettgeri, a major cause of traveler’s diarrhea.
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Designing of a Recombinant Multi-Epitopes Based Vaccine against Enterococcus mundtii Using Bioinformatics and Immunoinformatics Approaches
Metab Alharbi,Abdulrahman Alshammari,A. Alasmari,Salman Mansour Alharbi,Muhammad Tahir ul Qamar,Asad Ullah,Sajjad Ahmad,Muhammad Irfan,Atif A Khalil +8 more
TL;DR: A multi-epitope-based vaccine against E. mundtii is designed using in silico approaches and blind docking with immune cell receptors, followed by molecular dynamic simulation results confirms the good binding potency and stability of the vaccine in providing protection against the pathogen.
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Designing a Multi-Epitope Vaccine against Chlamydia trachomatis by Employing Integrated Core Proteomics, Immuno-Informatics and In Silico Approaches
Sidra Aslam,Sajjad Ahmad,Fatima Noor,Usman Ali Ashfaq,Farah Shahid,Abdur Rehman,Muhammad Tahir ul Qamar,Eid A. Alatawi,Fahad M. Alshabrmi,Khaled S Allemailem +9 more
TL;DR: In this article, the authors used core proteomics, immuno-informatics, and subtractive proteomics approaches to identify the best antigenic candidates for the development of a multi-epitope-based vaccine (MEBV).
References
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Journal ArticleDOI
Basic Local Alignment Search Tool
TL;DR: A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP) score.
Journal ArticleDOI
Molecular dynamics with coupling to an external bath.
TL;DR: In this paper, a method is described to realize coupling to an external bath with constant temperature or pressure with adjustable time constants for the coupling, which can be easily extendable to other variables and to gradients, and can be applied also to polyatomic molecules involving internal constraints.
Journal ArticleDOI
PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
Journal ArticleDOI
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
TL;DR: A new membrane protein topology prediction method, TMHMM, based on a hidden Markov model is described and validated, and it is discovered that proteins with N(in)-C(in) topologies are strongly preferred in all examined organisms, except Caenorhabditis elegans, where the large number of 7TM receptors increases the counts for N(out)-C-in topologies.
Journal ArticleDOI
I-TASSER server for protein 3D structure prediction.
TL;DR: The I-TASSER server has been developed to generate automated full-length 3D protein structural predictions where the benchmarked scoring system helps users to obtain quantitative assessments of the I- TASSER models.