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Journal ArticleDOI

Intelligent computing with Levenberg-Marquardt artificial neural networks for nonlinear system of COVID-19 epidemic model for future generation disease control.

TL;DR: An intelligent computing paradigm through Levenberg–Marquardt artificial neural networks (LMANNs) for solving the mathematical model of Corona virus disease 19 (COVID-19) propagation via human to human interaction is designed.
Abstract: The aim of this work is to design an intelligent computing paradigm through Levenberg-Marquardt artificial neural networks (LMANNs) for solving the mathematical model of Corona virus disease 19 (COVID-19) propagation via human to human interaction. The model is represented with systems of nonlinear ordinary differential equations represented with susceptible, exposed, symptomatic and infectious, super spreaders, infection but asymptomatic, hospitalized, recovery and fatality classes, and reference dataset of the COVID-19 model is generated by exploiting the strength of explicit Runge-Kutta numerical method for metropolitans of China and Pakistan including Wuhan, Karachi, Lahore, Rawalpindi and Faisalabad. The created dataset is arbitrary used for training, validation and testing processes for each cyclic update in Levenberg-Marquardt backpropagation for numerical treatment of the dynamics of COVID-19 model. The effectiveness and reliable performance of the design LMANNs are endorsed on the basis of assessments of achieved accuracy in terms of mean squared error based merit functions, error histograms and regression studies.

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Citations
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TL;DR: In this article, the authors investigated the bimodal spread of COVID-19 with hybrid model based on nonlinear autoregressive with radial base function (NAR-RBFs) neural network for SITR model.

91 citations

Journal ArticleDOI
TL;DR: In this paper, the nano-material flow of Ree-Eyring fluid model (NF-this paperM) is examined by utilizing the technique of Levenberg Marquardt with backpropagated neural networks (TLM-BNNs).

60 citations

Journal ArticleDOI
TL;DR: In this paper, artificial neural networks back-propagated with Levenberg Marquardt scheme (ANN-BLMS) is presented to analyze the entropy generation of carbon nanotubes (CNTs) between two rotating stretching discs under the influence of thermal radiation and magneto-hydrodynamic nano-fluid flow model.

59 citations

Journal ArticleDOI
TL;DR: In this paper, the authors used the Lie group analysis approach to compute the absolute invariants for the system of differential equations, which are solved numerically using Adams-Bashforth technique.
Abstract: Rheology of MHD bioconvective nanofluid containing motile microorganisms is inspected numerically in order to analyze heat and mass transfer characteristics. Bioconvection is implemented by combined effects of magnetic field and buoyancy force. Gyrotactic microorganisms enhance the heat and transfer as well as perk up the nanomaterials’ stability. Variable transport properties along with assisting and opposing flow situations are taken into account. The significant influences of thermophoresis and Brownian motion have also been taken by employing Buongiorno’s model of nanofluid. Lie group analysis approach is utilized in order to compute the absolute invariants for the system of differential equations, which are solved numerically using Adams-Bashforth technique. Validity of results is confirmed by performing error analysis. Graphical and numerical illustrations are prepared in order to get the physical insight of the considered analysis. It is observed that for controlling parameters corresponding to variable transport properties c2, c4, c6, and c8, the velocity, temperature, concentration, and bioconvection density distributions accelerates, respectively. While heat and mass transfer rates increases for convection parameter and bioconvection Rayleigh number, respectively.

44 citations

Journal ArticleDOI
TL;DR: A exhaustive analysis of the numerical solutions of GWNN-GA-SQP solver with reference Adams method endorse the stability, accuracy and consistency on multiple autonomous runs through different statistical performance operators and complexity analysis.

39 citations

References
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Journal ArticleDOI
TL;DR: The independent zoonotic transmission of SARS-CoV and SARS -CoV-2 highlights the need for studying viruses at the species level to complement research focused on individual pathogenic viruses of immediate significance.
Abstract: The present outbreak of a coronavirus-associated acute respiratory disease called coronavirus disease 19 (COVID-19) is the third documented spillover of an animal coronavirus to humans in only two decades that has resulted in a major epidemic. The Coronaviridae Study Group (CSG) of the International Committee on Taxonomy of Viruses, which is responsible for developing the classification of viruses and taxon nomenclature of the family Coronaviridae, has assessed the placement of the human pathogen, tentatively named 2019-nCoV, within the Coronaviridae. Based on phylogeny, taxonomy and established practice, the CSG recognizes this virus as forming a sister clade to the prototype human and bat severe acute respiratory syndrome coronaviruses (SARS-CoVs) of the species Severe acute respiratory syndrome-related coronavirus, and designates it as SARS-CoV-2. In order to facilitate communication, the CSG proposes to use the following naming convention for individual isolates: SARS-CoV-2/host/location/isolate/date. While the full spectrum of clinical manifestations associated with SARS-CoV-2 infections in humans remains to be determined, the independent zoonotic transmission of SARS-CoV and SARS-CoV-2 highlights the need for studying viruses at the species level to complement research focused on individual pathogenic viruses of immediate significance. This will improve our understanding of virus–host interactions in an ever-changing environment and enhance our preparedness for future outbreaks.

5,527 citations

Journal ArticleDOI
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Abstract: Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. Both viruses likely originated in bats, and genetically diverse coronaviruses that are related to SARS-CoV and MERS-CoV were discovered in bats worldwide. In this Review, we summarize the current knowledge on the origin and evolution of these two pathogenic coronaviruses and discuss their receptor usage; we also highlight the diversity and potential of spillover of bat-borne coronaviruses, as evidenced by the recent spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to pigs. Coronaviruses have a broad host range and distribution, and some highly pathogenic lineages have spilled over to humans and animals. Here, Cui, Li and Shi explore the viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome.

3,970 citations

Journal ArticleDOI
TL;DR: The approaches for developing effective vaccines and therapeutic combinations to cope with this viral outbreak are discussed and the emergence and pathogenicity of COVID-19 infection and previous human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory virus (MERS- coV) is analyzed.

2,643 citations

Journal ArticleDOI
TL;DR: In this paper, the authors proposed a new model that predicts the course of the SARS-CoV-2 pandemic to help plan an effective control strategy, including social distancing, testing and contact tracing.
Abstract: In Italy, 128,948 confirmed cases and 15,887 deaths of people who tested positive for SARS-CoV-2 were registered as of 5 April 2020. Ending the global SARS-CoV-2 pandemic requires implementation of multiple population-wide strategies, including social distancing, testing and contact tracing. We propose a new model that predicts the course of the epidemic to help plan an effective control strategy. The model considers eight stages of infection: susceptible (S), infected (I), diagnosed (D), ailing (A), recognized (R), threatened (T), healed (H) and extinct (E), collectively termed SIDARTHE. Our SIDARTHE model discriminates between infected individuals depending on whether they have been diagnosed and on the severity of their symptoms. The distinction between diagnosed and non-diagnosed individuals is important because the former are typically isolated and hence less likely to spread the infection. This delineation also helps to explain misperceptions of the case fatality rate and of the epidemic spread. We compare simulation results with real data on the COVID-19 epidemic in Italy, and we model possible scenarios of implementation of countermeasures. Our results demonstrate that restrictive social-distancing measures will need to be combined with widespread testing and contact tracing to end the ongoing COVID-19 pandemic.

1,432 citations

Journal ArticleDOI
TL;DR: A new epidemic model is proposed that discriminates between infected individuals depending on whether they have been diagnosed and on the severity of their symptoms, and shows how the basic reproduction number can be redefined in the new framework, thus capturing the potential for epidemic containment.
Abstract: In late December 2019, a novel strand of Coronavirus (SARS-CoV-2) causing a severe, potentially fatal respiratory syndrome (COVID-19) was identified in Wuhan, Hubei Province, China and is causing outbreaks in multiple world countries, soon becoming a pandemic. Italy has now become the most hit country outside of Asia: on March 16, 2020, the Italian Civil Protection documented a total of 27980 confirmed cases and 2158 deaths of people tested positive for SARS-CoV-2. In the context of an emerging infectious disease outbreak, it is of paramount importance to predict the trend of the epidemic in order to plan an effective control strategy and to determine its impact. This paper proposes a new epidemic model that discriminates between infected individuals depending on whether they have been diagnosed and on the severity of their symptoms. The distinction between diagnosed and non-diagnosed is important because non-diagnosed individuals are more likely to spread the infection than diagnosed ones, since the latter are typically isolated, and can explain misperceptions of the case fatality rate and of the seriousness of the epidemic phenomenon. Being able to predict the amount of patients that will develop life-threatening symptoms is important since the disease frequently requires hospitalisation (and even Intensive Care Unit admission) and challenges the healthcare system capacity. We show how the basic reproduction number can be redefined in the new framework, thus capturing the potential for epidemic containment. Simulation results are compared with real data on the COVID-19 epidemic in Italy, to show the validity of the model and compare different possible predicted scenarios depending on the adopted countermeasures.

858 citations