Interaction of aldehydes with glyoxalase I and the status of several aldehyde metabolizing enzymes of Ehrlich ascites carcinoma cells.
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Cites background from "Interaction of aldehydes with glyox..."
...Methylglyoxal is tumoricidal and inhibits glycolysis and mitochondrial respiration of Ehrlich ascites tumor cells, probably because of their low GLO I and GLO II levels and very low AKR enzyme activities (Biswas et al., 1996)....
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"Interaction of aldehydes with glyox..." refers background in this paper
...Laetaldehyde can significantly protect the respiratory ability of various intact malignant cells [8] and also ofmitochondria of EAC cells [ 10] against the inhibitory effect of methylglyoxal....
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...The work described in the present and in our previous papers have indicated that lactaldehyde may play a crucial role in the manifestation of the anticancer effect of methylglyoxal [8, 10]....
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...Interestingly, lactaldehyde is a protective agent against the action of methylglyoxal on intact tumor cells [8] and on mitochondria isolated from these cells [10]....
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...On the other hand, recent work from our laboratory has indicated that methylglyoxal is also tumoricidal [8]....
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...Of all these aldehydes tested lactaldehyde has been found to be the most powerful inhibitor_ As previously reported from our laboratory lactaldehyde can significantly influence the antitumor effect of methylglyoxal [8, 10]....
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