Interaction of antibiotics with functional sites in 16S ribosomal RNA
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...Nevertheless, naturally occurring tetracycline-resistant propionibacteria contain a cytosine-toguanine point mutation at position 1058 in 16S rRNA (251) (see below), which does at least suggest that the neighboring bases U1052 and C1054 identified by chemical footprinting (180) may have functional significance for the binding of tetracyclines to the 30S subunit....
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...Several studies have indicated a single, high-affinity binding site for tetracyclines in the ribosomal 30S subunit, with indications through photoaffinity labeling and chemical footprinting studies that protein S7 and 16S rRNA bases G693, A892, U1052, C1054, G1300, and G1338 contribute to the binding pocket (44, 180, 196, 263)....
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