Journal ArticleDOI
Interaction of chlorpromazine with myoglobin and hemoglobin: A comparative study
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TLDR
Thermodynamic analysis revealed that binding of CPZ to hemoglobin was exothermic, whereas binding to myoglobin was endothermic with a high entropic contribution, suggesting that CPZ binding toMyoglobin is hydrophobic in nature.About:
This article is published in Biochemical Pharmacology.The article was published on 1994-06-01. It has received 68 citations till now. The article focuses on the topics: Myoglobin & Binding constant.read more
Citations
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Journal ArticleDOI
Protein-flavonol interaction: fluorescence spectroscopic study.
TL;DR: Analysis of relevant spectroscopic data leads to the conclusions that two binding sites are involved in BSA–3HF interaction, and the interaction is slightly positively cooperative in nature with a similar binding constant.
Journal ArticleDOI
Betulinic acid binding to human serum albumin: A study of protein conformation and binding affinity
Rajagopal Subramanyam,Anilkishor Gollapudi,Persis Bonigala,Madhurarekha Chinnaboina,Damu G. Amooru +4 more
TL;DR: It is suggested that micro TOF-Q mass spectrometry is useful technique for drug binding studies after showing for the first time that BA isolated from a plant (Tephrosia calophylla) binds to HSA.
Journal ArticleDOI
Effect of nonenzymatic glycation on functional and structural properties of hemoglobin.
TL;DR: It is demonstrated that in the presence of H(2)O(2), HbA(1c) degrades DNA and protein more efficiently than Hb a(0) and formation of carbonyl content, an index of oxidative stress, is higher by H bA( 1c).
Journal ArticleDOI
Multiple non-psychiatric effects of phenothiazines: a review.
TL;DR: Information relating to the toxic and beneficial effects of these drugs has been discussed in this review and appropriate clinical application of phenothiazines can be developed in the future after gaining a comprehensive knowledge about their function.
Journal ArticleDOI
Spectroscopic studies on the interaction of morin–Eu(III) complex with calf thymus DNA
TL;DR: In this article, the interaction between morin-Eu(III) complex and calf thymus DNA in physiological buffer (pH 7.4) was investigated using UV-vis spectrophotometry, fluorescence spectroscopy, viscosity measurements and DNA melting techniques.
References
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Journal ArticleDOI
Myoglobin-facilitated oxygen diffusion: role of myoglobin in oxygen entry into muscle.
Journal ArticleDOI
Evidence for cooperative binding of chlorpromazine with hemoglobin: equilibrium dialysis, fluorescence quenching and oxygen release study.
TL;DR: Binding of chlorpromazine with human hemoglobin has been studied by equilibrium dialysis and fluorescence quenching and results revealed that the binding was positively cooperative with overall affinity constant K = 3.8 x 10(3) M-1.
Book ChapterDOI
Preparation of myoglobins.
TL;DR: This chapter presents procedures for the isolation of intracellular oxygen-binding proteins of tissues, called “tissue hemoglobins” in the widest sense, which are monomers or dimers having a minimum molecular weight of 18,000 with similar optical spectra and chemical reactivity.
Journal ArticleDOI
Irreversible binding of the chlorpromazine radical cation and of photoactivated chlorpromazine to biological macromolecules
N. J. De Mol,R.W. Busker +1 more
TL;DR: The irreversible binding of chlorpromazine radical cation (CPZ+.) and photoactivated chlor Promazine ( CPZ) to calf thymus DNA in vitro and bacterial macromolecules in intact bacterium cells was investigated and the consequences of covalent binding for the cytotoxicity and genotoxicity of CPZ+.
Journal ArticleDOI
Protein-ligand interactions: interaction of nitrosamines with nicotinic acetylcholine receptor.
TL;DR: Scatchard analysis indicates that all four ligands are true agonists of the receptor exhibiting positive cooperative binding with the existence of more than one class of binding site.
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