Interaction of L-myc oncogene in breast cancer with irinotecan onto functionalized magnetic nanoparticles
TL;DR: In this article, the effect of different functional groups on binding capacity of DNA was studied with bare and modified superparamagnetic iron oxide nanoparticles (SPIONs), where modifications were performed with [3-(2,3-epoxypropoxy)propyl] trimethoxy silane (GPTS) and (3-aminopropyl) triethoxysilane (APTS) by silanization reaction and also subsequent reaction with glutaraldehyde (GA) to obtain functional groups.
About: This article is published in Materials Letters.The article was published on 2013-09-01. It has received 10 citations till now.
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TL;DR: The results show that in one minute, organo-silane compound can be functionalized onto SPION through unique conditions generated from ultrasonic irradiation.
48 citations
TL;DR: A sonochemical method of functionalizing superparamagnetic iron oxide nanoparticles (SPION) with (3-aminopropyl)triethoxysilane (APTES) showed that the silanization reaction time was greatly minimized and the product displayedsuperparamagnetic behaviour at room temperature with more than 20% higher saturation magnetization.
Abstract: We report a sonochemical method of functionalizing superparamagnetic iron oxide nanoparticles (SPION) with (3-aminopropyl)triethoxysilane (APTES). Mechanical stirring, localized hot spots and other unique conditions generated by an acoustic cavitation (sonochemical) process were found to induce a rapid silanization reaction between SPION and APTES. FTIR, XPS and XRD measurements were used to demonstrate the grafting of APTES on SPION. Compared to what was reported in literature, the results showed that the silanization reaction time was greatly minimized. More importantly, the product displayed superparamagnetic behaviour at room temperature with a more than 20% higher saturation magnetization.
40 citations
TL;DR: In this article, new magnetic nanobiohybrid particles with a multilayered structure were prepared, which have a spherical shape and an average size of 147-20nm according to SEM images.
32 citations
TL;DR: Outcomes suggested that the engineered IRSLNFs hold great potential for targeting CRC for an extended period of time, and not only high %entrapment efficiency but also small particle size.
Abstract: Aim: The aim of this investigation was to evaluate the potential of folic acid-tailored solid lipid nanoparticles (SLNs) for encapsulation as well as for in vitro cytotoxicity study of irinotecan h...
16 citations
Cites background from "Interaction of L-myc oncogene in br..."
...Irinotecan hydrochloride trihydrate (IHT), a water-soluble semisynthetic derivative of camptothecin, frequently used in the management of CRC and malignancies related to small cells in the lung (Bansal et al. 2008, Maltas et al. 2013)....
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TL;DR: The binding of irinotecan to serum proteins (hemoglobin, globulin and human serum albumin) was studied on the surface of epoxide modified superparamagnetic iron oxide nanoparticles (GPTS-SPIONs), which were synthesized by the coprecipitation of ferrous and ferric salts with NH4OH.
14 citations
References
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TL;DR: It is found that most single base changes in up to 200-base fragments could be detected as mobility shifts and the interspersed repetitive sequences of human, Alu repeats are highly polymorphic.
3,625 citations
"Interaction of L-myc oncogene in br..." refers background in this paper
...expression is a commonly found molecular defect in human cancers [9,10]....
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TL;DR: The proposed structural change is compatible with the normal restrictions on bond lengths, angles, and non-bonded contacts, and maintenance of the hydrogen- bonded base pairs perpendicular to the axis of the molecule.
2,046 citations
"Interaction of L-myc oncogene in br..." refers background in this paper
...However, single- and double-strand breaks have been reported in isolated dublex DNA or PCR product by addition of small molecules [18–20]....
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TL;DR: PEG and folic acid modification of magnetite nanoparticles could be used to resist the protein adsorption and thus avoid the particle recognition by macrophage cells, and to facilitate the nanoparticle uptake to specific cancer cells for cancer therapy and diagnosis.
1,249 citations
"Interaction of L-myc oncogene in br..." refers background in this paper
...For past decades, magnetic nanoparticles (MNPs) immobilized DNA molecules on their surface is not only used for DNA extraction, they also used for gene therapy and drug delivery [1,2]....
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TL;DR: Data is indicated that these oncoproteins actually serve quite different roles in vivo, indicating that the deregulated expression of each MYC gene is reproducibly associated with only certain naturally occurring malignancies in humans and that these genes are not interchangeable with respect to their aberrant functional consequences.
Abstract: c-myc, N-myc and L-myc are the three members of the myc oncoprotein family whose role in the pathogenesis of many human neoplastic diseases has received wide empirical support. In this review, we first summarize data, derived mainly from non-clinical studies, indicating that these oncoproteins actually serve quite different roles in vivo. This concept necessarily lies at the heart of the basis for the observation that the deregulated expression of each MYC gene is reproducibly associated with only certain naturally occurring malignancies in humans and that these genes are not interchangeable with respect to their aberrant functional consequences. We also review evidence implicating each of the above MYC genes in specific neoplastic diseases and have attempted to identify unresolved questions which deserve further basic or clinical investigation. We have made every attempt to review those diseases for which significant and confirmatory evidence, based on studies with primary tumor material, exists to implicate MYC members in their causation and/or progression.
1,164 citations
"Interaction of L-myc oncogene in br..." refers background in this paper
...expression is a commonly found molecular defect in human cancers [9,10]....
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TL;DR: The role of MNP size, composition and surface chemistry in their intracellular uptake, biodistribution, macrophage recognition and cytotoxicity, and review current studies on MNP toxicity, caveats of nanotoxicity assessments and engineering strategies to optimize MNPs for biomedical use are discussed.
897 citations
"Interaction of L-myc oncogene in br..." refers background in this paper
...Importantly, application of high-gradient magnetic fields led to improved transduction efficiency in local transfection in both in vitro and in vivo studies [7,8]....
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