Journal ArticleDOI
Interaction of Prostaglandin F2α and Prostaglandin-E2 on Progesterone Production in Human Granulosa-Luteal Cells
Jeffrey E. Väänänen,Brenda Li Pak Tong,Céline C. M. Väänänen,Ivan Hok Hue Chan,Basil Ho Yuen,Peter C.K. Leung +5 more
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TLDR
Neither PGF< sub>2α</sub> nor PGE<sub>2</sub) alone were luteotrophic, although specific combinations of these hormones were, and two different combinations ofThese hormones led to at least a 3-fold increase in progesterone production.Abstract:
This study examined the effects of prostaglandin-F2α (PGF2α), prostaglandin-E2 (PGE2) and their interactions on progesterone production in human granulosa-lread more
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Ovarian reserve status in young women is associated with altered gene expression in membrana granulosa cells
Christine C. Skiadas,Shenghua Duan,Mick Correll,Renee Rubio,Nilay Karaca,Elizabeth S. Ginsburg,John Quackenbush,Catherine Racowsky +7 more
TL;DR: It is concluded that gene expression analysis has substantial potential to determine which young women may be affected with DOR and suggests that DOR patients fall into two distinct subgroups based on gene expression profiles, indicating that different mechanisms may be involved during development of this pathology.
Journal ArticleDOI
Interleukin-1β Stimulates Progesterone Production by in Vitro Human Luteal Cells: Evidence of a Mediatory Role of Prostaglandins
TL;DR: The data show the ability of IL-1 beta to influence P secretion via the COX pathway, thereby suggesting a possible luteotropic role in human ovary based on an autocrine-paracrine mechanism.
Journal ArticleDOI
PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11beta-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa lutein cells.
Christina Chandras,T E Harris,T E Harris,A López Bernal,D R E Abayasekara,A E Michael,A E Michael +6 more
TL;DR: Findings implicate the PTGER2 receptor–cAMP signalling pathway in the stimulation of progesterone production and 11βHSD1 activity by PGE2 in human granulosa–lutein cells.
Journal ArticleDOI
Mapping PTGERs to the Ovulatory Follicle: Regional Responses to the Ovulatory PGE2 Signal
Soon Ok Kim,Diane M. Duffy +1 more
TL;DR: Differential PTGER expression, coupled with activation of cell-specific intracellular signals, may explain how a single paracrine mediator can have pleotropic actions within the ovulatory follicle.
Journal ArticleDOI
The impact of parturition induction with cloprostenol on immunological parameters in the sow colostrum
TL;DR: An increased proportion of colostral lymphocytes can positively influence the cellular immunity transmission from sow to her offspring, and a lower lysozyme concentration can adversely affect newborn’s intestinal immunity, as well as changes in cytokine concentrations can have an adverse effect on newborn piglet intestinal epithelium development and its defence function.
References
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Cloning and expression of a cDNA for the human prostanoid IP receptor.
Mark Abramovitz,Yves Boie,Truyen Nguyen,Thomas H. Rushmore,M.A. Bayne,Kathleen M. Metters,Deborah Slipetz,Ryszard Grygorczyk +7 more
TL;DR: A cDNA clone coding for a functional human prostanoid IP receptor that is functionally coupled to a signaling pathway involving stimulation of intracellular cAMP production is cloned and expressed.
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Molecular Cloning and Characterization of the Human Prostanoid DP Receptor (
TL;DR: The cloned and expressed a functional cDNA for the hDP receptor showed the highest degree of identity with the hIP and hEP2 receptors, followed by the hEP4 receptor and the rank order of affinities for prostaglandins and prostaglandsin analogs was as predicted for the DP receptor.
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Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.
Colin D. Funk,Lucinda Furci,Garret A. FitzGerald,Ryszard Grygorczyk,C Rochette,M A Bayne,M Abramovitz,M Adam,Kathleen Metters +8 more
TL;DR: The human EP1 receptor subtype, a functional cDNA clone coding for the human prostaglandin E receptor EP1 subtype which is functionally coupled to an increase in intracellular Ca2+.
Journal ArticleDOI
Cloning and expression of a cDNA for mouse prostaglandin F receptor
Yukihiko Sugimoto,Ken Yuh Hasumoto,Tsunehisa Namba,Atsushi Irie,Masato Katsuyama,Manabu Negishi,Akira Kakizuka,Shuh Narumiya,Atsushi Ichikawa +8 more
TL;DR: RNA blot and in situ hybridization analyses demonstrated that the PGF receptor transcripts are abundantly expressed in luteal cells of corpus luteum and in a lesser amount in kidney, heart, stomach, and lung.