Journal ArticleDOI
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy
Lulu Jiang,Weiwei Lin,Cheng Zhang,Peter E.A. Ash,Mamta Verma,Julian Kwan,Emily van Vliet,Zhuo Yang,Anna Lourdes Cruz,Samantha Boudeau,Brandon F. Maziuk,Shuwen Lei,Jaehyup Song,Victor E. Alvarez,Stacy Hovde,Jose F. Abisambra,Min Hao Kuo,Nicholas M. Kanaan,Melissa E. Murray,John F. Crary,Jian Zhao,Ji-Xin Cheng,Leonard Petrucelli,Hu Li,Andrew Emili,Benjamin Wolozin +25 more
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TLDR
In this paper, the authors used Cry2-based optogenetics to induce tau oligomers (oTau-c), which elicits tau phosphorylation, aggregation, and reduced protein synthesis.About:
This article is published in Molecular Cell.The article was published on 2021-10-21. It has received 48 citations till now. The article focuses on the topics: Tau protein & Tauopathy.read more
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Tau liquid-liquid phase separation in neurodegenerative diseases.
TL;DR: Tau alone or in the presence of RNA has a high propensity to undergo liquid-liquid phase separation (LLPS), forming liquid droplets as mentioned in this paper , which may contribute to normal biological functions of the protein as well as to tau pathology in neurodegenerative diseases.
Journal ArticleDOI
RNA modifications: importance in immune cell biology and related diseases
Lian Cui,Rui Ma,Jiangli Cai,Chunyuan Guo,Zeyu Chen,Lina Yao,Yuanyuan Wang,Rui Fan,Xin Wang,Yuling Shi +9 more
TL;DR: In this article , the authors present existing knowledge of the biological functions and underlying mechanisms of RNA modifications, including N 6 -methyladenosine (m 6 A), 5-methylcytosine(m 5 C), N 1 -methyl adenosine,m 1 A), N 7 -methylguanosine (n 7 G), N 4 -acetylacetylcytusine (ac 4 C), pseudouridine (Ψ), uridylation, and A-to-I RNA editing, and summarize their critical roles in immune cell biology and highlight the challenges and future directions based on the existing knowledge.
Journal ArticleDOI
The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer.
Deepthi Ramesh-Kumar,Sonia Guil +1 more
TL;DR: In this paper , the regulatory roles of IGF2BP proteins and their molecular role as m6A modification readers to the cellular phenotype are summarized and a comprehensive insight into the IGF 2BP function is provided.
Journal ArticleDOI
Tau interactome and RNA binding proteins in neurodegenerative diseases
TL;DR: The authors in this paper provided a combined analysis of 12 tau interactome studies of human brain tissue, human cell culture models and rodent models of disease. But, despite the common presence of tau aggregates in these diseases the affected brain regions, clinical symptoms, and morphology, conformation, and isoform ratio present in tau aggregation varies widely.
Journal ArticleDOI
RNA induces unique tau strains and stabilizes Alzheimer’s disease seeds
TL;DR: In this article , the authors found that three RNA homopolymers, polyA, polyU, and polyC, all bound tau, but only polyA triggered seed and fibril formation.
References
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limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie,Belinda Phipson,Di Wu,Yifang Hu,Charity W. Law,Wei Shi,Gordon K. Smyth,Gordon K. Smyth +7 more
TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
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STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.
Damian Szklarczyk,Annika L. Gable,David Lyon,Alexander Junge,Stefan Wyder,Jaime Huerta-Cepas,Milan Simonovic,Nadezhda Tsankova Doncheva,John H. Morris,Peer Bork,Lars Juhl Jensen,Christian von Mering +11 more
TL;DR: The latest version of STRING more than doubles the number of organisms it covers, and offers an option to upload entire, genome-wide datasets as input, allowing users to visualize subsets as interaction networks and to perform gene-set enrichment analysis on the entire input.
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Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Lindsay A. Farrer,L. Adrienne Cupples,Jonathan L. Haines,Bradley T. Hyman,Walter A. Kukull,Richard Mayeux,Richard H. Myers,Margaret A. Pericak-Vance,Neil Risch,Cornelia M. van Duijn +9 more
TL;DR: The APOE∈4 allele represents a major risk factor for AD in all ethnic groups studied, across all ages between 40 and 90 years, and in both men and women.
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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
Denise Harold,Richard Abraham,Paul Hollingworth,Rebecca Sims,Amy Gerrish,Marian L. Hamshere,Jaspreet Singh Pahwa,Valentina Moskvina,Kimberley Dowzell,Amy L. Williams,Nicola L. Jones,Charlene Thomas,Alexandra Stretton,Angharad R. Morgan,Simon Lovestone,John Powell,Petroula Proitsi,Michelle K. Lupton,Carol Brayne,David C. Rubinsztein,Michael Gill,Brian A. Lawlor,Aoibhinn Lynch,Kevin Morgan,Kristelle Brown,Peter Passmore,David Craig,Bernadette McGuinness,Stephen Todd,Clive Holmes,David M. A. Mann,A. David Smith,Seth Love,Patrick G. Kehoe,John Hardy,Simon Mead,Nick C. Fox,Martin N. Rossor,John Collinge,Wolfgang Maier,Frank Jessen,Britta Schürmann,Hendrik van den Bussche,Isabella Heuser,Johannes Kornhuber,Jens Wiltfang,Martin Dichgans,Lutz Frölich,Harald Hampel,Harald Hampel,Michael Hüll,Dan Rujescu,Alison Goate,John S. K. Kauwe,Carlos Cruchaga,Petra Nowotny,John C. Morris,Kevin Mayo,Kristel Sleegers,Karolien Bettens,Sebastiaan Engelborghs,Peter Paul De Deyn,Christine Van Broeckhoven,Gill Livingston,Nicholas Bass,Hugh Gurling,Andrew McQuillin,Rhian Gwilliam,Panagiotis Deloukas,Ammar Al-Chalabi,Christopher Shaw,Magda Tsolaki,Andrew B. Singleton,Rita Guerreiro,Thomas W. Mühleisen,Markus M. Nöthen,Susanne Moebus,Karl-Heinz Jöckel,Norman Klopp,H-Erich Wichmann,Minerva M. Carrasquillo,V. Shane Pankratz,Steven G. Younkin,Peter Holmans,Michael Conlon O'Donovan,Michael John Owen,Julie Williams +86 more
TL;DR: A two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals, the most powerful AD GWAS to date, produced compelling evidence for association with Alzheimer's Disease in the combined dataset.
Journal ArticleDOI
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
Karen S. SantaCruz,Jada Lewis,Tara L. Spires,Jennifer B. Paulson,Linda Kotilinek,Martin Ingelsson,A. Guimaraes,Michael DeTure,Martin Ramsden,Eileen McGowan,Colleen L. Forster,Mei Yue,Jennifer D. Orne,Chris Janus,Ami Mariash,Michael A. Kuskowski,Bradley T. Hyman,Mike Hutton,Karen H. Ashe +18 more
TL;DR: NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy, and after the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to the authors' surprise, NFTs continued to accumulate.