Open AccessJournal Article
Interactome networks and human disease
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TLDR
Why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease are detailed.Abstract:
Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.read more
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The BioPlex Network: A Systematic Exploration of the Human Interactome
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The BioGRID Interaction Database: 2011 update
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TL;DR: The BioGRID 3.0 web interface contains new search and display features that enable rapid queries across multiple data types and sources that enable insights into conserved networks and pathways that are relevant to human health.
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