Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway
Xiaojin Sha,Shu Meng,Xinyuan Li,Hang Xi,Massimo Maddaloni,David W. Pascual,Huimin Shan,Xiaohua Jiang,Hong Wang,Xiaofeng Yang +9 more
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TLDR
It is suggested that IL-35 is an attractive novel therapeutic reagent for sepsis and cardiovascular diseases because it inhibits vascular response in acute inflammation and attenuates LPS-induced secretion of proinflammatory cytokines/chemokines.About:
This article is published in Journal of Biological Chemistry.The article was published on 2015-07-31 and is currently open access. It has received 81 citations till now. The article focuses on the topics: Proinflammatory cytokine & Inflammation.read more
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The Role of Cytokines in the Development of Atherosclerosis.
TL;DR: The latest findings on the role of cytokines in the development and progression of atherosclerosis are discussed, with a focus on pro-inflammatory cytokines, while anti- inflammatory cytokines ameliorate the disease.
Journal ArticleDOI
Vascular Endothelial Cells and Innate Immunity.
Ying Shao,Jason Saredy,William Y. Yang,Yu Sun,Yifan Lu,Fatma Saaoud,Charles Drummer,Candice Johnson,Keman Xu,Xiaohua Jiang,Hong Wang,Xiaofeng Yang +11 more
TL;DR: Recent advances are introduced that classify ECs as novel immune cells not only in infections and allograft transplantation but also in metabolic diseases and association of immune checkpoint inhibitors with cardiovascular adverse events and cardio-oncology indicates the potential contributions ofECs as innate immune cells.
Journal ArticleDOI
ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
Yu Sun,Yifan Lu,Jason Saredy,Xianwei Wang,Charles Drummer,Ying Shao,Fatma Saaoud,Keman Xu,Ming Liu,William Y. Yang,Xiaohua Jiang,Hong Wang,Xiaofeng Yang +12 more
TL;DR: This model proposes a working model that ROS systems are a new integrated network for sensing homeostasis and alarming stress in metabolic processes in various subcellular organelles and provides novel therapeutic targets for treating those diseases.
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A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors
Luqiao Wang,Luqiao Wang,Luqiao Wang,Gayani Nanayakkara,Qian Yang,Qian Yang,Hongmei Tan,Charles Drummer,Yu Sun,Ying Shao,Hangfei Fu,Ramon Cueto,Huimin Shan,Teodoro Bottiglieri,Ya-Feng Li,Candice Johnson,William Y. Yang,Fan Yang,Yanjie Xu,Hang Xi,Weiqing Liu,Jun Yu,Eric T. Choi,Xiaoshu Cheng,Hong Wang,Xiaofeng Yang +25 more
TL;DR: A new paradigm that most nuclear receptors are anti-inflammatory homeostasis-associated molecular pattern receptors (HAMPRs) is proposed to provide a novel insight on NRs as therapeutic targets in metabolic diseases, inflammations, and malignancies.
Journal ArticleDOI
MicroRNA-155 Deficiency Leads to Decreased Atherosclerosis, Increased White Adipose Tissue Obesity, and Non-alcoholic Fatty Liver Disease A NOVEL MOUSE MODEL OF OBESITY PARADOX
Anthony Virtue,Candice Johnson,Jahaira Lopez-Pastrana,Ying Shao,Hangfei Fu,Xinyuan Li,Ya-Feng Li,Ying Yin,Jietang Mai,Victor Rizzo,Michael G. Tordoff,Zsolt Bagi,Huimin Shan,Xiaohua Jiang,Hong Wang,Xiaofeng Yang +15 more
TL;DR: The findings suggest the mechanistic role of reduced miR-155 expression in OP and present a new OP working model based on a single miRNA deficiency in diet-induced obese atherogenic mice, serving as a breakthrough in understanding the potential mechanism underlying OP.
References
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Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.
Derek C. Angus,Walter T. Linde-Zwirble,Jeffrey Lidicker,Gilles Clermont,Joseph A. Carcillo,Michael R. Pinsky +5 more
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AP-1 as a regulator of cell life and death
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