International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
Dean M. Wingerchuk,Brenda Banwell,Jeffrey Bennett,Philippe Cabre,William M. Carroll,Tanuja Chitnis,Jérôme De Seze,Kazuo Fujihara,Benjamin Greenberg,Anu Jacob,Sven Jarius,Marco Aurélio Lana-Peixoto,Michael J. Levy,Jack H. Simon,Silvia Tenembaum,Anthony Traboulsee,Patrick Waters,Kay E. Wellik,Brian G. Weinshenker +18 more
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TLDR
The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus and achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasicNMOSD and opticospinal MS.Abstract:
Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted or more extensive CNS involvement may occur. The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus. The new nomenclature defines the unifying term NMO spectrum disorders (NMOSD), which is stratified further by serologic testing (NMOSD with or without AQP4-IgG). The core clinical characteristics required for patients with NMOSD with AQP4-IgG include clinical syndromes or MRI findings related to optic nerve, spinal cord, area postrema, other brainstem, diencephalic, or cerebral presentations. More stringent clinical criteria, with additional neuroimaging findings, are required for diagnosis of NMOSD without AQP4-IgG or when serologic testing is unavailable. The IPND also proposed validation strategies and achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasic NMOSD and opticospinal MS.read more
Citations
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Journal ArticleDOI
Myelin oligodendrocyte glycoprotein antibodies in neurological disease.
Markus Reindl,Patrick Waters +1 more
TL;DR: Antibodies against myelin oligodendrocyte glycoprotein (MOG-Abs) that are detectable with cell-based assays are associated with non-MS acquired demyelinating syndromes of the CNS, including the value of detection assays and evidence for antibody pathogenicity and its mechanism.
Journal ArticleDOI
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin.
Sven Jarius,Klemens Ruprecht,Ingo Kleiter,Nadja Borisow,Nasrin Asgari,Kalliopi Pitarokoili,Florence Pache,Oliver Stich,Lena-Alexandra Beume,Martin W. Hümmert,Corinna Trebst,Marius Ringelstein,Orhan Aktas,Alexander Winkelmann,Mathias Buttmann,Alexander Schwarz,Hanna Zimmermann,Alexander U. Brandt,Diego Franciotta,Marco Capobianco,Joseph Kuchling,Jürgen Haas,Mirjam Korporal-Kuhnke,Soeren Thue Lillevang,Kai Fechner,Kathrin Schanda,Friedemann Paul,Brigitte Wildemann,Markus Reindl +28 more
TL;DR: This is the largest cohort studied for IgG to human full-length MOG by means of an up-to-date CBA and finds MOG-IgG is present in a substantial subset of patients with ON and/or myelitis, but not in classical MS.
Journal ArticleDOI
Clinical spectrum and prognostic value of CNS MOG autoimmunity in adults: The MOGADOR study.
Alvaro Cobo-Calvo,Anne Ruiz,Elisabeth Maillart,Bertrand Audoin,Hélène Zéphir,Bertrand Bourre,Jonathan Ciron,Nicolas Collongues,David Brassat,François Cotton,Caroline Papeix,Françoise Durand-Dubief,David Laplaud,Romain Deschamps,Mikael Cohen,Damien Biotti,Xavier Ayrignac,Caroline Tilikete,Eric Thouvenot,Bruno Brochet,Cécile Dulau,Thibault Moreau,Ayman Tourbah,Pierre Lebranchu,Laure Michel,Christine Lebrun-Frenay,Alexis Montcuquet,Guillaume Mathey,Marc Debouverie,Jean Pelletier,Pierre Labauge,Nathalie Derache,M. Coustans,Fabien Rollot,Jérôme De Seze,Sandra Vukusic,Romain Marignier +36 more
TL;DR: In adults, MOG-Ab-associated disease extends beyond clinical and radiologic abnormalities in the optic nerve and spinal cord and despite the relapsing course, the overall visual and motor outcome is better compared with AQP4- Ab-positive patients.
Journal ArticleDOI
Mechanisms of Autoantibody-Induced Pathology.
Ralf Ludwig,Karen Vanhoorelbeke,Frank Leypoldt,Ziya Kaya,Katja Bieber,Sandra M. McLachlan,Lars Komorowski,Jie Luo,Otavio Cabral-Marques,Christoph M. Hammers,Jon Lindstrom,Peter Lamprecht,Andrea Fischer,Gabriela Riemekasten,Claudia Tersteeg,Peter Sondermann,Basil Rapoport,Klaus-Peter Wandinger,Christian Probst,Asmaa El Beidaq,Enno Schmidt,Alan S. Verkman,Rudolf A. Manz,Falk Nimmerjahn +23 more
TL;DR: autoantibodies can be classified into the following categories: mimic receptor stimulation, blocking of neural transmission, induction of altered signaling, triggering uncontrolled microthrombosis, cell lysis, neutrophil activation, and (7) induction of inflammation.
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Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome
Daniela Pohl,Gulay Alper,Keith Van Haren,Keith Van Haren,Andrew J. Kornberg,Claudia F. Lucchinetti,Silvia Tenembaum,Anita Belman +7 more
TL;DR: The current knowledge on epidemiology, pathology, clinical presentation, neuroimaging features, CSF findings, differential diagnosis, therapy, and outcome is summarized, with a focus on recent advances and controversies.
References
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Journal ArticleDOI
A serum autoantibody marker of neuromyelitis optica : distinction from multiple sclerosis
Vanda A. Lennon,Dean M. Wingerchuk,Thomas J. Kryzer,Sean J. Pittock,C. F. Lucchinetti,Kazuo Fujihara,Ichiro Nakashima,Brian G. Weinshenker +7 more
TL;DR: NMO-IgG is a specific marker autoantibody of neuromyelitis optica and binds at or near the blood-brain barrier that distinguishes neuromyleitis opticas from multiple sclerosis.
Journal ArticleDOI
Revised diagnostic criteria for neuromyelitis optica
TL;DR: Revised diagnostic criteria for definite neuromyelitis optica (NMO) that require optic neuritis, myelitis, and at least two of three supportive criteria: MRI evidence of a contiguous spinal cord lesion 3 or more segments in length, onset brain MRI nondiagnostic for multiple sclerosis, or NMO-IgG seropositivity.
Journal ArticleDOI
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.
TL;DR: It is shown that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier, which may represent the first example of a novel class of autoimmune channelopathy.
Journal ArticleDOI
The spectrum of neuromyelitis optica
Dean M. Wingerchuk,Vanda A. Lennon,Claudia F. Lucchinetti,Sean J. Pittock,Brian G. Weinshenker +4 more
TL;DR: Data suggest that autoantibodies to aquaporin 4 derived from peripheral B cells cause the activation of complement, inflammatory demyelination, and necrosis that is seen in neuromyelitis optica.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
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