Interplay Between Long-Range And Short-Range Interactions In Polymer Self-Assembly And Cell Adhesion
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TLDR
In this paper, reversible gelation of associating polymers and ligand-receptor interactions in membrane adhesion was studied, and the energy barrier of the adhesion as a result of membrane bending deformations and the double-well adhesion potential was calculated.Abstract:
Interplay between long-range and short-range interactions is a common theme in soft and biological matter, which results in complicated self-assembly behaviors. We study two examples of this interplay: reversible gelation of associating polymers and ligand-receptor interactions in membrane adhesion. In associating polymer solutions, the competition between the conformation flexibility of polymer chains and the enthalpic monomer interactions results in phase-separated micro-structures at the mesoscopic scale; both gelation and the microphase order-disorder transition are manifestations of this self-assembly. We further establish that reversible gelation is similar to the glass transition: both are characterized by ergodicity breaking, aperiodic micro-structures, and non-equilibrium relaxations over a finite temperature range. In the study of ligand-receptor interactions between surfaces, we emphasize the interplay between specific ligand-receptor binding, and generic physical interactions. We find that both the finite spatial extension of receptors and their mobilities affect their binding affinity. As a special case of the interplay between receptor binding and generic interactions, we study the dynamics of membrane adhesion that is mediated by receptor binding but fulfilled through membrane deformations. We calculate the energy barrier of the adhesion as a result of membrane bending deformations and the double-well adhesion potential, and analyze the different scenarios according to the shape of the adhesion potential by scaling arguments.read more
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References
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Journal ArticleDOI
Mesoscopic dynamics of copolymer melts: From density dynamics to external potential dynamics using nonlocal kinetic coupling
TL;DR: In this article, non-local kinetic coupling is applied to the dynamic mean-field density functional method, derived from generalized time-dependent Ginzburg-Landau theory, which was previously simulated using a local coupling approximation.
Journal ArticleDOI
Kinetics of membrane adhesion mediated by ligand-receptor interaction studied with a biomimetic system
TL;DR: The first measurement of the kinetics of adhesion of a single giant vesicle controlled by the competition between membrane-substrate interaction mediated by ligand-receptor interaction, gravitation, and Helfrich repulsion is reported.
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Morphologies of microphase-separated A2B simple graft copolymers
Darrin J. Pochan,Samuel P. Gido,Stergios Pispas,Jimmy W. Mays,Anthony J. Ryan,J. Patrick A. Fairclough,Ian W. Hamley,Nicholas J. Terrill +7 more
TL;DR: In this paper, the morphological behavior of simple graft block copolymers is characterized via small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM).
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Gelation in Physically Associating Polymer Solutions
Sanat K. Kumar,Jack F. Douglas +1 more
TL;DR: In this article, the authors show that at high temperatures, interchain associations relax over microscopic time scales, so that geometrical percolation is unrelated to macroscopic gelation, but with decreasing temperature, the stickers undergo a clustering transition, resulting in a transient localization of stickers and hence the chains.