Interplay between Reactive oxygen Species and MicroRNAs in Cancer.
Jun He,Bing-Hua Jiang +1 more
Reads0
Chats0
TLDR
The discovery of ROS-responsive microRNAs provides a potential new strategy to specifically overcome ROS-mediated tumor progression or benefit from ROS-induced apoptosis.Abstract:
As both reactive oxygen species (ROS) production and microRNA expression signature have been associated with tumor development, progression, metastasis, and therapeutic response, it is important to understand the crosstalk between ROS and microRNAs. Indeed, growing evidence suggests a reciprocal connection between ROS signaling and microRNA pathway, resulting in diverse biological effects in cancer cells. In this mini review, we discussed the ROS-responsive microRNAs that have implications in cancer and the possible mechanisms in which ROS regulate microRNAs. We also highlighted the microRNAs which are able to modify cellular ROS homeostasis during tumorigenesis, their biological targets and subsequent functions. As the use of antioxidants is limited due to the diverse or even opposing roles of ROS signaling in cancer, the discovery of ROS-responsive microRNAs provides a potential new strategy to specifically overcome ROS-mediated tumor progression or benefit from ROS-induced apoptosis.read more
Citations
More filters
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
Journal ArticleDOI
Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus.
TL;DR: This review presents the molecular mechanisms by which the oxidative milieu contributes to the pathophysiology of insulin resistance and diabetes mellitus through several molecular mechanisms.
Journal ArticleDOI
The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system
TL;DR: An overview of the role of ROS in modulating the epigenetic landscape in the context of the cardiovascular system is provided and it becomes more and more clear that epigenetic modifications are highly dynamic.
Journal ArticleDOI
Genetic alterations in hepatocellular carcinoma: An update.
TL;DR: The current advances in research on the genetic alterations, including genomic instability, single-nucleotide polymorphisms, somatic mutations and deregulated signaling pathways, implicated in the initiation and progression of HCC are summarized.
Journal ArticleDOI
Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?
Nelly D. Saenen,Dries S. Martens,Kristof Y. Neven,Rossella Alfano,Hannelore Bové,Brigitte Janssen,Harry A. Roels,Michelle Plusquin,Karen Vrijens,Tim S. Nawrot,Tim S. Nawrot +10 more
TL;DR: It is shown that prenatal exposure to air pollution is associated with nitrosative stress and epigenetic alterations in the placenta, and a potential co-interaction of different biological mechanisms on the level of placental oxidative stress, epigenetics, aging, and energy metabolism is extended.
References
More filters
Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
Journal ArticleDOI
Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.