Intestinal Permeability Defects: Is It Time to Treat?
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Cites background from "Intestinal Permeability Defects: Is..."
...Some argue that the leaky gut is only an outcome of disease progression rather than an initiator or exacerbator of disease (109), but this should not be the case for T1D....
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292 citations
Cites background from "Intestinal Permeability Defects: Is..."
...Unau 0951-7367 2014 Wolters Kluwer Health | Lippincott Williams & Wilk disorders, asthma, IBD and, speculatively, to mental health [65,66], although it is important to note that most data are correlational at this stage [67]....
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References
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"Intestinal Permeability Defects: Is..." refers background in this paper
...122 Aepithelium, is to form a barrier that prevents potentially noxious contents of the intestinal lumen, including the microbiota, from accessing internal sites and the systemic circulation.(1) Barrier defects have been reliably associated with a variety of human diseases, including those primarily affecting the gut, eg, inflammatory bowel disease (IBD), celiac disease, and irritable bowel syndrome (IBS), as well as systemic diseases or diseases involving other organ systems, eg, type I diabetes, graft-versushost disease (GVHD), human immunodeficiency virus, multiple sclerosis, rheumatoid arthritis, and autism....
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...Indeed, data from some mouse studies indicate that mild permeability increases may activate immunoregulatory pathways that can limit colitis on subsequent challenge.(1,43) 688...
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...These have been termed pore and leak pathways and refer to high capacity, sizeselective and charge-selective routes and low capacity, nonselective routes, respectively.(1,10) IL-13 specifically increases flux across the pore pathway by up-regulating expression of the tight junction protein claudin-2, which forms a paracellular cation and water channel....
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...Together with high-resolution in vitro analyses of tight junction size selectivity, this has led to a model in which there are at least 2 distinct routes of paracellular flux across the tight junction.(1,6,10) These have been termed pore and leak pathways and refer to high capacity, sizeselective and charge-selective routes and low capacity, nonselective routes, respectively....
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"Intestinal Permeability Defects: Is..." refers background in this paper
...Bacterial translocation has been postulated to cause immune activation.(67) Yes (in patients)(68)...
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"Intestinal Permeability Defects: Is..." refers background in this paper
...Type I diabetes Increased in pre-diabetic and diabetic patients(61) Yes(62) Unknown Changes in microbiome modify incidence of experimental disease.(63,64) Unknown...
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