Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis.
Reads0
Chats0
About:
This article is published in Biochemical Journal.The article was published on 1992-01-01 and is currently open access. It has received 1940 citations till now. The article focuses on the topics: Creatine transport & Phosphocreatine.read more
Citations
More filters
Journal ArticleDOI
Ischemic Cell Death in Brain Neurons
TL;DR: A major unifying thread of the review is a consideration of how the changes occurring during and after ischemia conspire to produce damaging levels of free radicals and peroxynitrite to activate calpain and other Ca(2+)-driven processes that are damaging, and to initiate the apoptotic process.
Journal ArticleDOI
Creatine and Creatinine Metabolism
Markus Wyss,Rima Kaddurah-Daouk +1 more
TL;DR: A comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism is presented, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of the enzymes and metabolites involved, and of the inherent implications for physiology and human pathology.
Journal ArticleDOI
Skeletal Muscle Fatigue: Cellular Mechanisms
TL;DR: Most of the mechanistic studies of fatigue are on isolated animal tissues, and another major challenge is to use the knowledge generated in these studies to identify the mechanisms of fatigue in intact animals and particularly in human diseases.
Journal ArticleDOI
The failing heart--an engine out of fuel.
TL;DR: This review describes cardiac energy metabolism, appraises the methods used for its assessment, evaluates the role of impaired energy metabolism in heart failure, and gives options for metabolic therapy.
Journal ArticleDOI
Myocardial Phosphocreatine-to-ATP Ratio Is a Predictor of Mortality in Patients With Dilated Cardiomyopathy
Stefan Neubauer,Michael Horn,Monika Cramer,Kerstin Harre,John B. Newell,Werner Peters,Thomas Pabst,Georg Ertl,Dietbert Hahn,Joanne S. Ingwall,Kurt Kochsiek +10 more
TL;DR: The myocardial phosphocreatine-to-ATP ratio, measured noninvasively with 31P-MR spectroscopy, is a predictor of both total and cardiovascular mortality in patients with dilated cardiomyopathy.
Related Papers (5)
Transport of energy in muscle: the phosphorylcreatine shuttle
Samuel P. Bessman,Paul J. Geiger +1 more