Intracellular trafficking of yeast telomerase components
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...Whether this functions (Ferrezuelo et al., 2002; Teixeira et al., 2002). template-recognition element directly binds to TERT or Human telomerase RNA, also a pol II transcript, has a interacts with another portion of the RNA remains a snoRNP (small nucleolar RNP) domain, appears to be question for…...
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Cites background from "Intracellular trafficking of yeast ..."
...High levels of telomerase activity result in continuous telomere elongation In budding yeast, overexpression of the TR subunit TLC1 together with the TERT subunit Est2p also results in higher telomerase activity levels in cell extracts (Teixeira et al, 2002)....
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"Intracellular trafficking of yeast ..." refers background in this paper
...Telomerase is a ribonucleoprotein (RNP) polymerase that uses an internal RNA moiety as template for the synthesis of telomere repeats (Greider and Blackburn, 1989; Lingner et al., 1997b)....
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1,293 citations
"Intracellular trafficking of yeast ..." refers background or result in this paper
...Telomerase is a ribonucleoprotein (RNP) polymerase that uses an internal RNA moiety as template for the synthesis of telomere repeats (Greider and Blackburn, 1989; Lingner et al., 1997b)....
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...Thus, Est1p and Est3p do not influence the steady-state localization of Est2p and TLC1 or their association, which is consistent with previous studies showing that Est1p and Est3p are not required for telomerase activity in vitro (Cohn and Blackburn, 1995; Lingner et al., 1997a)....
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...Active telomerase is localized in the nucleoplasm Telomerase activity requires Est2p and TLC1, which together make up the catalytic core (Lingner et al., 1997b)....
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1,122 citations
"Intracellular trafficking of yeast ..." refers background in this paper
...In support of this, it was shown that vertebrate telomerase RNA contains an H/ACA motif that targets the RNA to nucleoli where it was hypothesized to associate with the catalytic subunit of telomerase (Mitchell et al., 1999; Lukowiak et al., 2001)....
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"Intracellular trafficking of yeast ..." refers background in this paper
...Since the nucleolus is considered to be a site with a high concentration of trans-acting factors required for the assembly of ribosomes and other RNPs (Pederson, 1998; Sleeman and Lamond, 1999; Venema and Tollervey, 1999), it may provide factors that assist in the assembly of telomerase....
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