Intracortical and Thalamocortical Connections of the Hand and Face Representations in Somatosensory Area 3b of Macaque Monkeys and Effects of Chronic Spinal Cord Injuries.
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109 citations
Cites background from "Intracortical and Thalamocortical C..."
...In fact, there is little anatomical evidence that the face-elicited activity in SI is mediated by the growth of new cortico-cortical projections: Very few axons cross the face–hand boundary in SI of intact animals (see [57] for analogous results in humans revealed with neuroimaging) and deafferentation of the hand region does not result in any measurable increase in these boundary-crossing projections [58]....
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97 citations
Cites background from "Intracortical and Thalamocortical C..."
...…more limited than initially thought, and that instead the functional changes previously observed in S1 following input loss could be attributed to reorganisation in sub-cortical areas in the afferent pathway, principally the brainstem (Jain et al., 1998; Kambi et al., 2014; Chand and Jain, 2015)....
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70 citations
Cites background from "Intracortical and Thalamocortical C..."
...It has been suggested that the initial remapping triggered by deprivation will become refined by inputs due to daily hand usage involving compensatory behaviours (Churchill et al., 1998; Elbert et al., 1997)....
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63 citations
Cites background from "Intracortical and Thalamocortical C..."
...However, a recent definitive study showed that in monkeys with chronic lesions of the dorsal column of spinal cord that had resulted in large-scale map reorganization of hand and face representations in area 3b, nevertheless showed a striking absence of new intracortical projections across the hand–face border (Chand and Jain 2015)....
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31 citations
References
168 citations
"Intracortical and Thalamocortical C..." refers background in this paper
...In rat whisker barrel cortex, whisker pairing plasticity is more robust across rows compared with across arcs (Armstrong-James et al., 1994), which corresponds with richer intrinsic connections across rows than arcs (Hoeflinger et al....
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...In rat whisker barrel cortex, whisker pairing plasticity is more robust across rows compared with across arcs (Armstrong-James et al., 1994), which corresponds with richer intrinsic connections across rows than arcs (Hoeflinger et al., 1995)....
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165 citations
"Intracortical and Thalamocortical C..." refers background in this paper
...Such sprouting, if present, may not be expressed physiologically (Lane et al., 1995) but could play a role in shaping the novel receptive fields of neurons resulting from reorganizational changes at the medullary level (Faggin et al., 1997; Ergenzinger et al., 1998)....
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163 citations
"Intracortical and Thalamocortical C..." refers background in this paper
...Similarly, intrinsic connections play a role in plasticity in the motor cortex and visual cortex (Huntley, 1997; Calford et al., 2003) and help in shaping of isoorientation tuned neuronal responses in V1 (Shushruth et al., 2012)....
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153 citations
"Intracortical and Thalamocortical C..." refers background in this paper
...Intrinsic connections restricted to functional compartments have been observed in other systems, including visual, auditory, and motor cortex (Huntley and Jones, 1991; Yoshioka et al., 1996; Read et al., 2001; Ahmed et al., 2012)....
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152 citations
"Intracortical and Thalamocortical C..." refers background or methods in this paper
...In normal monkeys, thalamocortical connections were plotted following injections of BDA in D1 representation in Monkeys 09-51NM and 10-31NM, FR in D1 representation in Monkey 11-22NM, and FR in chin representation in Monkey 09-51NM. Plots of retrogradely labeled neurons in VP nucleus of monkeys with injection of neuroanatomical tracer in D1 showed that neurons were confined to the medial-most region of the hand subnucleus of ventral posterior lateral nucleus (VPL), along the lamina between the VPL and VPM (Fig....
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...However, location of the hand–face border, which is near tip of the intraparietal sulcus, was easy to determine, even in monkeys with lesions, because eliciting neuronal responses to chin stimulation in the deafferented hand region required taps instead of light touch (Jain et al., 2008)....
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...In the two remaining monkeys (LM105 and LM95), the cortex was not flattened be- cause they were also part of other experiments; therefore, position of the hand–face border was placed near the tip of the intraparietal sulcus (Jain et al., 2008) and estimated from the somatotopic map....
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...The animals were given antibiotics (enrofloxacin; 5 mg/kg, i.m.), analgesics (diclofenac 1.6 mg/kg, i.m.), and dexamethasone (in reducing dosages starting with 2 mg/kg, i.m.) for 5 d after surgery (Jain et al., 2008)....
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...…boundaries in the cortex after large deafferentations, such as transection of the dorsal columns (10 –14 mm, and sometimes more that 20 mm, Jain et al., 2008) or transection of dorsal roots (Pons et al., 1991), is beyond what can be mediated by normal connections in the brain,…...
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