Intracortical and Thalamocortical Connections of the Hand and Face Representations in Somatosensory Area 3b of Macaque Monkeys and Effects of Chronic Spinal Cord Injuries.
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109 citations
Cites background from "Intracortical and Thalamocortical C..."
...In fact, there is little anatomical evidence that the face-elicited activity in SI is mediated by the growth of new cortico-cortical projections: Very few axons cross the face–hand boundary in SI of intact animals (see [57] for analogous results in humans revealed with neuroimaging) and deafferentation of the hand region does not result in any measurable increase in these boundary-crossing projections [58]....
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97 citations
Cites background from "Intracortical and Thalamocortical C..."
...…more limited than initially thought, and that instead the functional changes previously observed in S1 following input loss could be attributed to reorganisation in sub-cortical areas in the afferent pathway, principally the brainstem (Jain et al., 1998; Kambi et al., 2014; Chand and Jain, 2015)....
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70 citations
Cites background from "Intracortical and Thalamocortical C..."
...It has been suggested that the initial remapping triggered by deprivation will become refined by inputs due to daily hand usage involving compensatory behaviours (Churchill et al., 1998; Elbert et al., 1997)....
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63 citations
Cites background from "Intracortical and Thalamocortical C..."
...However, a recent definitive study showed that in monkeys with chronic lesions of the dorsal column of spinal cord that had resulted in large-scale map reorganization of hand and face representations in area 3b, nevertheless showed a striking absence of new intracortical projections across the hand–face border (Chand and Jain 2015)....
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31 citations
References
103 citations
"Intracortical and Thalamocortical C..." refers background or methods in this paper
...The hand–face border, which is easily seen in histological sections as myelin-light septa in different species of monkeys (Jain et al., 1998b; Iyengar et al., 2007), likely forms a limiting boundary for information exchange between regions receiving nonadjacent peripheral inputs from hand and face....
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...In all these cases, the cortex was flattened and a series of alternate sections was stained for myelin to reveal the HFS (Jain et al., 1998b), which confirmed that the injection core did not cross the hand– face border....
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...…of intact chin inputs into the deafferented hand region of primary somatosensory area 3b, second somatosensory area S2, parietal ventral area PV (Jain et al., 1997, 1998a; Kaas et al., 2008; Tandon et al., 2009), ventroposterior (VP) nucleus of Received May 26, 2015; revised Aug. 24, 2015;…...
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...Adjacent sections, stained for myelin, were drawn at the same magnification, and myeloarchitectonic features and HFS were marked (Jain et al., 1998b)....
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...Other series of sections were stained for myelin using a modified Gallyas procedure (Jain et al., 1998b) to visualize the hand–face border in area 3b, which is visible as hand–face septum (HFS) (Fig....
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98 citations
"Intracortical and Thalamocortical C..." refers background in this paper
...…of brain plasticity is of interest for development of brain– computer interface devices and neuroprostheses because postinjury plasticity can undermine control of devices, or if properly managed, facilitate a better interface (e.g., Enzinger et al., 2008; Jain, 2010; Collignon et al., 2011)....
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98 citations
"Intracortical and Thalamocortical C..." refers background or methods in this paper
...In normal monkeys, thalamocortical connections were plotted following injections of BDA in D1 representation in Monkeys 09-51NM and 10-31NM, FR in D1 representation in Monkey 11-22NM, and FR in chin representation in Monkey 09-51NM. Plots of retrogradely labeled neurons in VP nucleus of monkeys with injection of neuroanatomical tracer in D1 showed that neurons were confined to the medial-most region of the hand subnucleus of ventral posterior lateral nucleus (VPL), along the lamina between the VPL and VPM (Fig....
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...There was sparing of the medial part of fasciculus cuneatus and nearly complete touch on the chin (Kambi et al., 2014, somatotopic map of their Fig....
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..., 2008), and cuneate nucleus of the brainstem (Kambi et al., 2014)....
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...that drives cortical reorganization (Kambi et al., 2014)....
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...We have recently shown that reorganization of the cuneate nucleus is the critical change that drives cortical reorganization (Kambi et al., 2014)....
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93 citations
"Intracortical and Thalamocortical C..." refers background or methods in this paper
...The Jones laboratory has examined connectivity across the hand–face border in macaque monkeys (Manger et al., 1997)....
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...Because data from normal macaque monkeys are extremely limited (Manger et al., 1997), we also determined the intrinsic connections in normal monkeys....
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92 citations
"Intracortical and Thalamocortical C..." refers background in this paper
...Similarly, intrinsic connections play a role in plasticity in the motor cortex and visual cortex (Huntley, 1997; Calford et al., 2003) and help in shaping of isoorientation tuned neuronal responses in V1 (Shushruth et al., 2012)....
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