Intranasally Administered Neuropeptide S (NPS) Exerts Anxiolytic Effects Following Internalization Into NPS Receptor-Expressing Neurons
Irina A. Ionescu,Julien Dine,Yi-Chun Yen,Dominik R. Buell,Leonie Herrmann,Florian Holsboer,Matthias Eder,Rainer Landgraf,Ulrike Schmidt +8 more
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TLDR
The results not only enlighten the path of NPS in the brain, but also establish a non-invasive method for NPS administration in mice, thus strongly encouraging translation into a novel therapeutic approach for pathological anxiety in humans.About:
This article is published in Neuropsychopharmacology.The article was published on 2012-01-25 and is currently open access. It has received 79 citations till now. The article focuses on the topics: Neuropeptide S & Internalization.read more
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Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
TL;DR: The data provide the first evidence that nasally applied OXT indeed reaches behaviorally relevant brain areas, and this uptake is paralleled by changes in plasma OXT.
Journal ArticleDOI
Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?
Guy Griebel,Florian Holsboer +1 more
TL;DR: Preclinical and clinical results for neuropeptide receptor ligands that have been studied in clinical trials for psychiatric diseases, including agents that target the receptors for tachykinins, corticotropin-releasing factor, vasopressin and neurotensin are analyzed and new ways to exploit the full potential of these candidate drugs are suggested.
Journal ArticleDOI
Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats.
Lidia I. Serova,Andrej Tillinger,Lishay G. Alaluf,Marcela Laukova,K. Keegan,Esther L. Sabban +5 more
TL;DR: Results show that single IN NPY can alter stress-triggered dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and activation of central noradrenergic activity.
Journal ArticleDOI
Animal models in translational studies of PTSD.
Nikolaos P. Daskalakis,Nikolaos P. Daskalakis,Rachel Yehuda,Rachel Yehuda,David M. Diamond,David M. Diamond +5 more
TL;DR: The current review covers recent translational approaches to bridge the gap between human and animal PTSD research and to create a framework for discovery of biomarkers and novel therapeutics.
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Intranasal neuropeptide Y reverses anxiety and depressive-like behavior impaired by single prolonged stress PTSD model.
TL;DR: Intranasal NPY reversed several behavioral impairments triggered by the traumatic stress of SPS and has potential for non-invasive PTSD therapeutic intervention.
References
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