Journal ArticleDOI
Intrathecal morphine in mice: a new technique.
J. L.K. Hylden,George L. Wilcox +1 more
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A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described, and submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia.About:
This article is published in European Journal of Pharmacology.The article was published on 1980-10-17. It has received 1823 citations till now. The article focuses on the topics: Morphine & (+)-Naloxone.read more
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A potent and selective endogenous agonist for the mu-opiate receptor.
TL;DR: The discovery and isolation from brain of a peptide, endomorphin-1 (Tyr-Pro-Trp-Phe-NH2), which has the highest specificity and affinity for the µ receptor of any endogenous substance so far described and they maybe natural ligands for this receptor.
Journal ArticleDOI
Different immune cells mediate mechanical pain hypersensitivity in male and female mice
Robert E. Sorge,Josiane C.S. Mapplebeck,Sarah F. Rosen,Simon Beggs,Sarah Taves,Jessica K. Alexander,Loren J. Martin,Jean-Sebastien Austin,Susana G. Sotocinal,Di Chen,Mu Yang,Xiang Qun Shi,Hao Huang,Nicolas J. Pillon,Philip J. Bilan,Yu Shan Tu,Amira Klip,Ru-Rong Ji,Ji Zhang,Michael W. Salter,Jeffrey S. Mogil +20 more
TL;DR: It is found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypers sensitivity using adaptive immune cells, likely T lymphocytes, suggesting that male mice cannot be used as proxies for females in pain research.
Journal ArticleDOI
A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
Yan-Gang Sun,Zhou-Feng Chen +1 more
TL;DR: The results indicate that GRPR may represent the first molecule that is dedicated to mediating the itch sensation in the dorsal horn of the spinal cord, and thus may provide a central therapeutic target for antipruritic drug development.
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Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
Zhen-Zhong Xu,Ling Zhang,Tong Liu,Jong Yeon Park,Temugin Berta,Rong Yang,Charles N. Serhan,Ru-Rong Ji +7 more
TL;DR: It is reported that peripheral or spinal administration of RvE1 or RvD1 in mice potently reduces inflammatory pain behaviors induced by intraplantar injection of formalin, carrageenan or complete Freund's adjuvant without affecting basal pain perception.
References
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A simplified method of evaluating dose-effect experiments.
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: The method provides means for the rapid test of parallelism of two curves and easy computation of relative potency with its confidence limits and its accuracy is commensurate with the nature of dose-per cent effect data.
Journal Article
A simplified method of evaluating dose-effect experiments
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: In this article, a rapid graphic method for approximating the median effective dose and the slope of dose-per-cent effect curves is presented, and confidence limits of both of these parameters for 19/20 probability are given by the method.
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A method for determining loss of pain sensation
Fred E. D'Amour,Donn L. Smith +1 more
TL;DR: A simple, rapid method for determining the pain threshold in the rat was applied to the determination of analgesic properties of several substances, including cobra venom, where no analgesic property in the latter could be demonstrated.
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Chronic catheterization of the spinal subarachnoid space.
Tony L. Yaksh,Thomas A. Rudy +1 more
TL;DR: Calibration experiments revealed that there was little rostro-caudal diffusion of the injectate along the spinal axis and that even for compounds such as naloxone which can rapidly permeate neural tissues, the levels which do appear in the brain are small following the spinal subarachnoid administration of the drug.
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Analgesia mediated by a direct spinal action of narcotics.
Tony L. Yaksh,T. A. Rudy +1 more
TL;DR: Narcotic analgetics administered directly into the spinal subarachnoid space of the rat via a chronically inserted catheter produce a potent analgesia that can be antagonized by naloxone.