Intravascular Large B-Cell Lymphoma: A Difficult Diagnostic Challenge.
Citations
81 citations
Cites background from "Intravascular Large B-Cell Lymphoma..."
...The World Health Organization reports neoplastic cells will be found within the lumina of small and intermediatesized vessels, with prominent nucleoli, scant cytoplasm, and frequent mitotic figures.(3) Some variability of IVLBCL cell characteristics has been observed, particularly including cases with coarse nuclear chromatin and irregular nuclei, cells of sizes smaller than expected, limited extravasation of neoplastic cells, involvement of larger veins and arteries than expected, and involvement of the walls of major vessels....
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...The Asian form of IVLBCL has been historically described as occurring predominantly in Japan, characterized by multi-organ failure, hepatosplenomegaly, pancytopenia, and hemophagocytic syndrome.(3) Some have suggested that concomitant presence or absence of Figure 1....
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...Intravascular lymphoma is most frequently a disease of B lymphocytes, although rare cases of thymus-cell (T-cell) and natural killer–cell disease have been reported;(6) the World Health Organization considers these cases to be a separate entity.(3) Intravascular large B-cell lymphoma is aggressive, and has historically been a rapidly fatal malignancy when diagnosis and treatment is delayed....
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66 citations
59 citations
Cites background from "Intravascular Large B-Cell Lymphoma..."
...IVL is a rare subtype of extranodal diffuse large B-cell lymphoma.(1) It is characterized by a propensity for intravascular proliferation of tumor cells in small vessels with a predilection for the central nervous system and skin....
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49 citations
Cites background or methods from "Intravascular Large B-Cell Lymphoma..."
...Intravascular large B-cell lymphoma (IVLBCL) is a distinct type of extranodal diffuse large B-cell lymphoma (DLBCL) characterized by selective growth of lymphoma cells within the lumen of small blood vessels (Nakamura et al, 2008; Nakamura et al, 2017)....
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...We retrospectively reviewed the records of patients who were diagnosed with IVLBCL according to the 2008 World Health Organization criteria (Nakamura et al, 2008) and its revision (Nakamura et al, 2017)....
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48 citations
References
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"Intravascular Large B-Cell Lymphoma..." refers background in this paper
...The most commonly involved sites in this lymphoma are skin and brain, but it can involve any organ.(5) It has 2 major subtypes: “Western” subtype with skin and neurologic involvement and “Asian” subtype that presents as a hemophagocytic syndrome with multiorgan involvement....
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268 citations
"Intravascular Large B-Cell Lymphoma..." refers background in this paper
...IVLBCL, also known as angiotropic large cell lymphoma,1,2 was first described in 1959 by Pfleger and Tappeiner.3 It was formerly known as “malignant angioendotheliomatosis.”...
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...IVLBCL, also known as angiotropic large cell lymphoma,(1,2) was first described in 1959 by Pfleger and Tappeiner.(3) It was formerly known as “malignant angioendotheliomatosis....
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240 citations
"Intravascular Large B-Cell Lymphoma..." refers background in this paper
...Intravascular large cell B-cell lymphoma (IVLBCL) is a malignancy confined to the lumina of small blood vessels without any extravascular tumor mass or circulating lymphoma cells in the peripheral blood or bone marrow.(1) IVLBCL is rare, and as of 2007, only about 300 cases have been reported, mostly involving B cells (IVLBCL)....
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