Journal ArticleDOI
Intrinsic antibiotic resistance: Mechanisms, origins, challenges and solutions
Georgina Cox,Gerard D. Wright +1 more
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TLDR
The possibility of inhibiting elements comprising the intrinsic resistome in bacterial pathogens offers the promise for repurposing existing antibiotics against intrinsically resistant bacteria.About:
This article is published in International Journal of Medical Microbiology.The article was published on 2013-08-01. It has received 435 citations till now. The article focuses on the topics: Resistome & Antibiotic resistance.read more
Citations
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Antibacterial drug discovery in the resistance era
Eric D. Brown,Gerard D. Wright +1 more
TL;DR: The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians, researchers, policymakers, politicians and the public at large as discussed by the authors, and the evolution and widespread distribution of antibiotic-resistant elements in bacterial pathogens has made diseases that were once easily treatable deadly again.
Journal ArticleDOI
Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria
Clayton W. Hall,Thien-Fah Mah +1 more
TL;DR: This review summarises both historical and recent scientific data in support of the known biofilm resistance and tolerance mechanisms and suggestions for future work in the field are provided.
Journal ArticleDOI
An overview of the antimicrobial resistance mechanisms of bacteria
TL;DR: Understanding more about the mechanisms of resistance should hopefully lead to better treatment options for infective diseases, and development of antimicrobial drugs that can withstand the microorganisms attempts to become resistant.
Journal ArticleDOI
Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators
TL;DR: It is argued that the lack of environment-facing mitigation actions included in existing AMR action plans is likely a function of the authors' poor fundamental understanding of many of the key issues and the science to inform policy is lacking and this needs to be addressed.
Journal ArticleDOI
Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens.
Elizabeth Peterson,Parjit Kaur +1 more
TL;DR: A conceptual framework for understanding the complexity of the problem of emergence of antibiotic resistance in the clinic is provided and the relationships between resistance determinants found in producer soil bacteria, non-producer environmental bacteria, and clinical isolates are explored.
References
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Journal ArticleDOI
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
TL;DR: This review summarizes the development in the field since the previous review and begins to understand how this bilayer of the outer membrane can retard the entry of lipophilic compounds, owing to increasing knowledge about the chemistry of lipopolysaccharide from diverse organisms and the way in which lipopoly Saccharide structure is modified by environmental conditions.
Journal ArticleDOI
Antibiotic resistance is ancient
Vanessa M. D'Costa,Christine E. King,Lindsay Kalan,Mariya Morar,Wilson W L Sung,Carsten Schwarz,Duane G. Froese,Grant D. Zazula,Fabrice Calmels,Régis Debruyne,G. Brian Golding,Hendrik N. Poinar,Gerard D. Wright +12 more
TL;DR: Target metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments are reported and show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use.
Journal ArticleDOI
Agents that increase the permeability of the outer membrane.
TL;DR: Chelators (such as EDTA, nitrilotriacetic acid, and sodium hexametaphosphate), which disintegrate the outer membrane by removing Mg2+ and Ca2+, are effective and valuable permeabilizers.
Journal ArticleDOI
Inactivation of antibiotics and the dissemination of resistance genes.
TL;DR: Although bacterial conjugation once was believed to be restricted in host range, it now appears that this mechanism of transfer permits genetic exchange between many different bacterial genera in nature.
Book
Biochemistry of lipids, lipoproteins, and membranes
Dennis E. Vance,Jean E. Vance +1 more
TL;DR: This chapter discusses the physical properties and functional Roles of Lipids in Membranes, as well as the Dynamics of Lipoprotein Transport in the Circulatory System.
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